Management of menopause: a view towards prevention

RA Lobo, A Gompel - The Lancet Diabetes & Endocrinology, 2022 - thelancet.com
Women spend approximately one-third of their lives with menopause, which occurs around
50 years of age. It is now appreciated that several important metabolic and cardiovascular …

Endogenous and exogenous estrogen exposures: how women's reproductive health can drive brain aging and inform Alzheimer's prevention

S Jett, N Malviya, E Schelbaum, G Jang… - Frontiers in Aging …, 2022 - frontiersin.org
After advanced age, female sex is the major risk factor for late-onset Alzheimer's disease
(AD), the most common cause of dementia affecting over 24 million people worldwide. The …

FSH blockade improves cognition in mice with Alzheimer's disease

J Xiong, SS Kang, Z Wang, X Liu, TC Kuo, F Korkmaz… - Nature, 2022 - nature.com
Alzheimer's disease has a higher incidence in older women, with a spike in cognitive
decline that tracks with visceral adiposity, dysregulated energy homeostasis and bone loss …

Reproductive factors and the risk of incident dementia: a cohort study of UK Biobank participants

J Gong, K Harris, SAE Peters, M Woodward - PLoS Medicine, 2022 - journals.plos.org
Background Women's reproductive factors have been associated with the risk of dementia;
however, these findings remain uncertain. This study aimed to examine the risk of incident …

Is hormone replacement therapy a risk factor or a therapeutic option for Alzheimer's disease?

ZB Mills, RLM Faull, A Kwakowsky - International Journal of Molecular …, 2023 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that accounts for
more than half of all dementia cases in the elderly. Interestingly, the clinical manifestations of …

[HTML][HTML] Menopause and cognitive impairment: a narrative review of current knowledge

DM Conde, RC Verdade, ALR Valadares… - World journal of …, 2021 - ncbi.nlm.nih.gov
A severe impairment of cognitive function characterizes dementia. Mild cognitive impairment
represents a transition between normal cognition and dementia. The frequency of cognitive …

Hormone therapy in the postmenopausal years: considering benefits and risks in clinical practice

AR Genazzani, P Monteleone… - Human reproduction …, 2021 - academic.oup.com
BACKGROUND Menopausal symptoms can be very distressing and considerably affect a
woman's personal and social life. It is becoming more and more evident that leaving …

Obesity-induced cognitive impairment in older adults: a microvascular perspective

P Balasubramanian, T Kiss… - American Journal …, 2021 - journals.physiology.org
Over two-thirds of individuals aged 65 and older are obese or overweight in the United
States. Epidemiological data show an association between the degree of adiposity and …

FSH-blocking therapeutic for osteoporosis

S Gera, TC Kuo, AA Gumerova, F Korkmaz, D Sant… - Elife, 2022 - elifesciences.org
Pharmacological and genetic studies over the past decade have established the follicle-
stimulating hormone (FSH) as an actionable target for diseases affecting millions, namely …

Role of estrogen in women's Alzheimer's disease risk as modified by APOE

AC Valencia‐Olvera… - Journal of …, 2023 - Wiley Online Library
Alzheimer's disease (AD) is characterized by numerous sexual dimorphisms that impact the
development, progression, and probably the strategies to prevent and treat the most …