Genomic instability is the hallmark of various cancers with the increasing accumulation of
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …

DNA mismatch repair (MMR) requires coordinated sequential actions of multiple proteins
during a window of time after the replication apparatus makes an error and before the newly …

DNA mismatch repair (MMR) relies on MutS and MutL ATPases for mismatch recognition
and strand-specific nuclease recruitment to remove mispaired bases in daughter strands …

Abstract Highly conserved MutS and MutL homologs operate as protein dimers in mismatch
repair (MMR). MutS recognizes mismatched nucleotides forming ATP-bound sliding clamps …

Immune Checkpoint Inhibitors (ICIs) have remarkably modified the way solid tumors are
managed, including breast cancer. Unfortunately, only a relatively small number of breast …

In budding yeast, the MutL homolog heterodimer Mlh1-Mlh3 (MutLγ) plays a central role in
the formation of meiotic crossovers. It is also involved in the repair of a subset of mismatches …

The pathological huntingtin (HTT) trinucleotide repeat underlying Huntington disease (HD)
continues to expand throughout life. Repeat length correlates both with earlier age at onset …

In eukaryotic mismatch repair, MutS homologs recognize mismatches and recruit the MutLα
endonuclease which introduces a nick in the newly replicated, error-containing DNA strand …

DNA mismatch repair (MMR), the guardian of the genome, commences when MutS identifies
a mismatch and recruits MutL to nick the error-containing strand, allowing excision and DNA …

In their life cycle, plants are exposed to various unfavorable environmental factors including
ultraviolet (UV) radiation emitted by the Sun. UV-A and UV-B, which are partially absorbed …