Acute myeloid leukemia (AML) is a genetically heterogeneous disease that, even with
current advancements in therapy, continues to have a poor prognosis. Recurrent somatic …

Simple Summary Myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are clonal
myeloid neoplasms characterized, at the time of their presentation, by the simultaneous …

Hematopoietic stem cell transplantation (HSCT) represents the standard treatment for
patients with high or intermediate-2 risk (IPSS classification) myelodysplastic syndrome …

Somatic mutations in hotspot regions of the cytosolic or mitochondrial isoforms of the
isocitrate dehydrogenase gene (IDH1 and IDH2, respectively) contribute to the …

Context.—Myelodysplasia cutis is an emerging concept in cutaneous neoplasia. Many of
these cases were previously included under the umbrella of histiocytoid Sweet syndrome …

Relapse is the main cause of treatment failure for leukaemia patients with unfavourable
gene mutations who receive allogeneic haematopoietic stem cell transplantation (allo …

Development of next-generation sequencing (NGS) has provided useful genetic information
to redefine diagnostic, prognostic, and therapeutic strategies for the management of acute …

Background Myeloid neoplasms (MN) tend to relapse and deteriorate. Exploring the
genomic mutation landscape of MN using next‐generation sequencing (NGS) is a great …

Copy number variants (CNVs) and gene mutations are important for diagnosis and treatment
of myeloid malignancies. In a routine clinical setting, somatic gene mutations are detected …

Background Alternative splicing (AS), a crucial post-transcriptional regulatory mechanism in
expanding the coding capacities of genomes and increasing the diversity of proteins, still …