Increased longevity and population aging will increase the number of men with late onset
hypogonadism. It is a common condition, but often underdiagnosed and undertreated. The …

The effects of estrogens are pleiotropic, affecting multiple bodily systems. Changes from the
body's natural fluctuating levels of estrogens, through surgical removal of the ovaries …

Alzheimer's disease has a higher incidence in older women, with a spike in cognitive
decline that tracks with visceral adiposity, dysregulated energy homeostasis and bone loss …

Alzheimer's disease (AD) is the most common dementia. It is known that women with one
ApoE4 allele display greater risk and earlier onset of AD compared with men. In mice, we …

A mechanistic understanding of aging has yet to be described; this paper puts forth a new
theory that has the potential to explain aging in all sexually reproductive life forms. The …

Average testosterone levels and many cognitive functions show a decline with age. There is
evidence to suggest that this association is not just age related. Results from cell culture and …

Leuprolide acetate is a synthetic nonapeptide that is a potent gonadotropin-releasing
hormone receptor (GnRHR) agonist used for diverse clinical applications, including the …

The purpose of this study was to assess pituitary gonadotropins and free testosterone levels
in a larger cohort of men with Alzheimer's disease (AD, n= 112) and age-matched controls …

Until recently, the study of hormonal influences in Alzheimer disease was limited to the role
of sex steroids. Despite numerous epidemiological studies supporting a protective role for …

Objective To determine whether gonadotropin levels are elevated in patients with Alzheimer
disease (AD). Patients and Methods We measured luteinizing hormone (LH) and follicle …