Healthy aging and human longevity are intricate phenotypes affected by environmental
factors such as physical exercise, diet, health habits, and psychosocial situations as well as …

Longer human lives have led to a global burden of late-life disease. However, some older
people experience little ill health, a trait that should be extended to the general population …

Alzheimer's disease (AD) is considered a polygenic disorder. This view is clouded, however,
by lingering uncertainty over how to treat the quasi" monogenic" role of apolipoprotein E …

Here we summarize the latest data on genetic and epigenetic contributions to human aging
and longevity. Whereas environmental and lifestyle factors are important at younger ages …

Aging populations face diminishing quality of life due to increased disease and morbidity.
These challenges call for longevity research to focus on understanding the pathways …

Survival to extreme ages clusters within families. However, identifying genetic loci conferring
longevity and low morbidity in such longevous families is challenging. There is debate …

Aging is a complex process indicated by low energy levels, declined physiological activity,
stress induced loss of homeostasis leading to the risk of diseases and mortality. Recent …

Using samples from the New England Centenarian Study (NECS), we sought to characterize
the serum proteome of 77 centenarians, 82 centenarians' offspring, and 65 age‐matched …

The urinary microbiome is a relatively unexplored niche that varies with gender. Urinary
microbes, especially in aging populations, are associated with morbidity. We present a large …

Frailty is a complex late life phenotype characterized by cumulative declines in multiple
physiological systems that increases the risk for disability and mortality. The biological …