The complexities of malaria disease manifestations with a focus on asymptomatic malaria
DD Laishram, PL Sutton, N Nanda, VL Sharma… - Malaria journal, 2012 - Springer
Malaria is a serious parasitic disease in the developing world, causing high morbidity and
mortality. The pathogenesis of malaria is complex, and the clinical presentation of disease …
mortality. The pathogenesis of malaria is complex, and the clinical presentation of disease …
MBL-associated serine proteases (MASPs) and infectious diseases
The lectin pathway of the complement system has a pivotal role in the defense against
infectious organisms. After binding of mannan-binding lectin (MBL), ficolins or collectin 11 to …
infectious organisms. After binding of mannan-binding lectin (MBL), ficolins or collectin 11 to …
Complement activation in malaria: friend or foe?
S Biryukov, JA Stoute - Trends in molecular medicine, 2014 - cell.com
Complement is activated during malaria infection, but there is little evidence that it benefits
the host. On the contrary, growing evidence points to the central role of complement …
the host. On the contrary, growing evidence points to the central role of complement …
A comprehensive in silico analysis of non-synonymous and regulatory SNPs of human MBL2 gene
Mannose binding lectin (MBL) is a liver derived protein which plays an important role in
innate immunity. Mannose binding lectin gene 2 (MBL2) polymorphisms are reported to be …
innate immunity. Mannose binding lectin gene 2 (MBL2) polymorphisms are reported to be …
Leprosy Association with Low MASP-2 Levels Generated by MASP2 Haplotypes and Polymorphisms Flanking MAp19 Exon 5
Background The gene MASP2 (mannan-binding lectin (MBL)-associated serine protease 2)
encodes two proteins, MASP-2 and MAp19 (MBL-associated protein of 19 kDa), bound in …
encodes two proteins, MASP-2 and MAp19 (MBL-associated protein of 19 kDa), bound in …
MBL2 Variations and Malaria Susceptibility in Indian Populations
AN Jha, P Sundaravadivel, VK Singh, SS Pati… - Infection and …, 2014 - Am Soc Microbiol
Human mannose-binding lectin (MBL) encoded by the MBL2 gene is a pattern recognition
protein and has been associated with many infectious diseases, including malaria. We …
protein and has been associated with many infectious diseases, including malaria. We …
Susceptibility to leprosy is associated with M-ficolin polymorphisms
ABW Boldt, MIN Sanchez, ERS Stahlke… - Journal of clinical …, 2013 - Springer
Purpose Mycobacterium leprae exploits complement activation and opsonophagocytosis to
infect phagocytes. M-ficolin is encoded by the FCN1 gene and initiates the lectin pathway on …
infect phagocytes. M-ficolin is encoded by the FCN1 gene and initiates the lectin pathway on …
Genetically determined MBL deficiency is associated with protection against chronic cardiomyopathy in Chagas disease
PR Luz, MI Miyazaki, N Chiminacio Neto… - PLoS neglected …, 2016 - journals.plos.org
Chagas disease (CD) is caused by Trypanosoma cruzi, whose sugar moieties are
recognized by mannan binding lectin (MBL), a soluble pattern-recognition molecule that …
recognized by mannan binding lectin (MBL), a soluble pattern-recognition molecule that …
Mannose-binding lectin and susceptibility to schistosomiasis
Background. Human ficolin 2 (encoded by FCN2) and mannose-binding lectin (encoded by
MBL2) bind to specific pathogen-associated molecular patterns, activate the complement …
MBL2) bind to specific pathogen-associated molecular patterns, activate the complement …
Multiplex sequence-specific polymerase chain reaction reveals new MASP2 haplotypes associated with MASP-2 and MAp19 serum levels
Deficiency of mannan-binding lectin-associated serine protease 2 (MASP-2) has been
associated with infections, whereas high levels appear to increase the risk of inflammatory …
associated with infections, whereas high levels appear to increase the risk of inflammatory …