A brave new world of RNA-binding proteins

MW Hentze, A Castello, T Schwarzl… - Nature reviews Molecular …, 2018 - nature.com
RNA-binding proteins (RBPs) are typically thought of as proteins that bind RNA through one
or multiple globular RNA-binding domains (RBDs) and change the fate or function of the …

Ribosomal proteins: functions beyond the ribosome

X Zhou, WJ Liao, JM Liao, P Liao… - Journal of molecular cell …, 2015 - academic.oup.com
Although ribosomal proteins are known for playing an essential role in ribosome assembly
and protein translation, their ribosome-independent functions have also been greatly …

Uncovering the assembly pathway of human ribosomes and its emerging links to disease

KE Bohnsack, MT Bohnsack - The EMBO journal, 2019 - embopress.org
The essential cellular process of ribosome biogenesis is at the nexus of various signalling
pathways that coordinate protein synthesis with cellular growth and proliferation. The fact …

[HTML][HTML] Regulation of translation initiation in eukaryotes: mechanisms and biological targets

N Sonenberg, AG Hinnebusch - Cell, 2009 - cell.com
Translational control in eukaryotic cells is critical for gene regulation during nutrient
deprivation and stress, development and differentiation, nervous system function, aging, and …

Regulation of ribosomal protein genes: An ordered anarchy

C Petibon, M Malik Ghulam, M Catala… - Wiley Interdisciplinary …, 2021 - Wiley Online Library
Ribosomal protein genes are among the most highly expressed genes in most cell types.
Their products are generally essential for ribosome synthesis, which is the cornerstone for …

Post-transcriptional regulation of gene expression in innate immunity

S Carpenter, EP Ricci, BC Mercier, MJ Moore… - Nature Reviews …, 2014 - nature.com
Innate immune responses combat infectious microorganisms by inducing inflammatory
responses, antimicrobial pathways and adaptive immunity. Multiple genes within each of …

How common are extraribosomal functions of ribosomal proteins?

JR Warner, KB McIntosh - Molecular cell, 2009 - cell.com
Ribosomal proteins are ubiquitous, abundant, and RNA binding: prime candidates for
recruitment to extraribosomal functions. Indeed, they participate in balancing the synthesis of …

New functions of aminoacyl-tRNA synthetases beyond translation

M Guo, XL Yang, P Schimmel - Nature reviews Molecular cell biology, 2010 - nature.com
Over the course of evolution, eukaryotic aminoacyl-tRNA synthetases (aaRSs) progressively
incorporated domains and motifs that have no essential connection to aminoacylation …

Aminoacyl‐tRNA synthetases in medicine and disease

P Yao, PL Fox - EMBO molecular medicine, 2013 - embopress.org
Aminoacyl‐tRNA synthetases (ARSs) are essential and ubiquitous 'house‐keeping'enzymes
responsible for charging amino acids to their cognate tRNAs and providing the substrates for …

Translational control of immune responses: from transcripts to translatomes

CA Piccirillo, E Bjur, I Topisirovic, N Sonenberg… - Nature …, 2014 - nature.com
Selective translational control of gene expression is emerging as a principal mechanism for
the regulation of protein abundance that determines a variety of functions in both the …