Next-generation sequencing platforms
ER Mardis - Annual review of analytical chemistry, 2013 - annualreviews.org
Automated DNA sequencing instruments embody an elegant interplay among chemistry,
engineering, software, and molecular biology and have built upon Sanger's founding …
engineering, software, and molecular biology and have built upon Sanger's founding …
Breaking the concentration limit of optical single-molecule detection
Over the last decade, single-molecule detection has been successfully utilized in the life
sciences and materials science. Yet, single-molecule measurements only yield meaningful …
sciences and materials science. Yet, single-molecule measurements only yield meaningful …
Revealing the cell–material interface with nanometer resolution by focused ion beam/scanning electron microscopy
The interface between cells and nonbiological surfaces regulates cell attachment, chronic
tissue responses, and ultimately the success of medical implants or biosensors. Clinical and …
tissue responses, and ultimately the success of medical implants or biosensors. Clinical and …
Iridium oxide nanotube electrodes for sensitive and prolonged intracellular measurement of action potentials
Intracellular recording of action potentials is important to understand electrically-excitable
cells. Recently, vertical nanoelectrodes have been developed to achieve highly sensitive …
cells. Recently, vertical nanoelectrodes have been developed to achieve highly sensitive …
Length-independent DNA packing into nanopore zero-mode waveguides for low-input DNA sequencing
Compared with conventional methods, single-molecule real-time (SMRT) DNA sequencing
exhibits longer read lengths than conventional methods, less GC bias, and the ability to read …
exhibits longer read lengths than conventional methods, less GC bias, and the ability to read …
High-throughput platform for real-time monitoring of biological processes by multicolor single-molecule fluorescence
Zero-mode waveguides provide a powerful technology for studying single-molecule real-
time dynamics of biological systems at physiological ligand concentrations. We customized …
time dynamics of biological systems at physiological ligand concentrations. We customized …
Zero-Mode waveguide nanowells for single-molecule detection in living cells
S Yang, N Klughammer, A Barth, ME Tanenbaum… - ACS …, 2023 - ACS Publications
Single-molecule fluorescence imaging experiments generally require sub-nanomolar
protein concentrations to isolate single protein molecules, which makes such experiments …
protein concentrations to isolate single protein molecules, which makes such experiments …
Inside-out neuropharmacology of nicotinic drugs
BJ Henderson, HA Lester - Neuropharmacology, 2015 - Elsevier
Upregulation of neuronal nicotinic acetylcholine receptors (AChRs) is a venerable result of
chronic exposure to nicotine; but it is one of several consequences of pharmacological …
chronic exposure to nicotine; but it is one of several consequences of pharmacological …
Menthol alone upregulates midbrain nAChRs, alters nAChR subtype stoichiometry, alters dopamine neuron firing frequency, and prevents nicotine reward
BJ Henderson, TR Wall, BM Henley… - Journal of …, 2016 - Soc Neuroscience
Upregulation of β2 subunit-containing (β2*) nicotinic acetylcholine receptors (nAChRs) is
implicated in several aspects of nicotine addiction, and menthol cigarette smokers tend to …
implicated in several aspects of nicotine addiction, and menthol cigarette smokers tend to …
Ultrabright bowtie nanoaperture antenna probes studied by single molecule fluorescence
We report on a novel design for the fabrication of ultrabright bowtie nanoaperture antenna
(BNA) probes to breach the intrinsic trade-off between power transmission and field …
(BNA) probes to breach the intrinsic trade-off between power transmission and field …