Finite element analysis (FEA) is a computational method providing numerical solutions and
mathematical modeling of complex physical phenomena that evolve during compression …

Capping is one of the major problems that occur during the tabletting process in the
pharmaceutical industry. This study provided an effective method for evaluating the capping …

A numerical study of the tableting process using a finite element method (FEM) is important
to quantitatively understand the structural change inside the tablet and the mechanism of …

Pharmaceutical manufacturing processes are necessary to make solid dosage form even in
cocrystal formation. In an effort to reduce the number of unit operations, high-shear wet …

Abstract Effects of residual stresses on the mechanical characteristics of tablets such as
tensile strength (TS) and disintegration time (DT) were investigated. The residual stresses …

Abstract The Drucker–Prager cap (DPC) model is useful for estimating stress and strain
distributions in compacted powders; however, it requires numerous stress state parameters …

Various stresses and strains are generated on the surface and inside of pharmaceutical
tablets when an external force is applied. In addition, stresses in various directions can …

The stress distribution of tablets after compression was simulated using a finite element
method, where the powder was defined by the Drucker–Prager cap model. The effect of …

A multivariate statistical technique was applied to clarify the causal correlation between
variables in the manufacturing process and the residual stress distribution of tablets …

In this study, we evaluated the correlation between the response surfaces for the tablet
characteristics of placebo and active pharmaceutical ingredient (API)-containing tablets. The …