Human brains vary across people and over time; such variation is not yet understood in
cellular terms. Here we describe a relationship between people's cortical neurons and …

The idiopathic generalized epilepsies (IGE) make up a fifth of all epilepsies, but< 1% of
epilepsy research. This skew reflects misperceptions: diagnosis is straightforward …

Epilepsy is a group of brain disorders characterised by an enduring predisposition to
generate unprovoked seizures. Fuelled by advances in sequencing technologies and …

Abstract Background Copy-number variations (CNVs) have been associated with rare and
debilitating genomic disorders (GDs) but their impact on health later in life in the general …

Objective Familial mesial temporal lobe epilepsy (FMTLE) is an important focal epilepsy
syndrome; its molecular genetic basis is unknown. Clinical descriptions of FMTLE vary …

Previous studies have indicated a potential relationship between zinc and epilepsy. The aim
of this study is to investigate the causal relationship between zinc, zinc-dependent carbonic …

Background Telomeres form repeated DNA sequences at the ends of chromosomes, which
shorten with each cell division. Yet, factors modulating telomere attrition and the health …

Background There is a profound connection between abnormal sleep patterns and brain
disorders, suggesting a shared influential association. However, the shared genetic basis …

Background and Objectives Epilepsies are associated with differences in cortical thickness
(TH) and surface area (SA). However, the mechanisms underlying these relationships …

6 Zhang L, Zhou Y, Wang Y, et al. Inhibiting PAC1 receptor internalization and endosomal
ERK pathway activation may ameliorate hyperalgesia in a chronic migraine rat model …