Cutaneous leishmaniasis: immune responses in protection and pathogenesis
Cutaneous leishmaniasis is a major public health problem and causes a range of diseases
from self-healing infections to chronic disfiguring disease. Currently, there is no vaccine for …
from self-healing infections to chronic disfiguring disease. Currently, there is no vaccine for …
The role of senescent T cells in immunopathology
LP Covre, RPH De Maeyer, DCO Gomes… - Aging cell, 2020 - Wiley Online Library
The development of senescence in tissues of different organs and in the immune system are
usually investigated independently of each other although during ageing, senescence in …
usually investigated independently of each other although during ageing, senescence in …
NKG2D promotes CD8 T cell-mediated cytotoxicity and is associated with treatment failure in human cutaneous leishmaniasis
LA Sacramento, C Farias Amorim… - PLOS Neglected …, 2023 - journals.plos.org
Cutaneous leishmaniasis exhibits a spectrum of clinical presentations dependent upon the
parasites' persistence and host immunopathologic responses. Although cytolytic CD8 T cells …
parasites' persistence and host immunopathologic responses. Although cytolytic CD8 T cells …
CD8+ T cells in cutaneous leishmaniasis: the good, the bad, and the ugly
CD8+ T lymphocytes are components of the adaptive immune response and play an
important role in protection against many viral and bacterial infections. However, their role in …
important role in protection against many viral and bacterial infections. However, their role in …
The role of CD4 and CD8 T cells in human cutaneous leishmaniasis
C da Silva Santos, CI Brodskyn - Frontiers in public health, 2014 - frontiersin.org
Leishmaniasis, caused by infection with parasites of the Leishmania genus, affects millions
of individuals worldwide. This disease displays distinct clinical manifestations ranging from …
of individuals worldwide. This disease displays distinct clinical manifestations ranging from …
Engagement of NKG2D on Bystander Memory CD8 T Cells Promotes Increased Immunopathology following Leishmania major Infection
One of the hallmarks of adaptive immunity is the development of a long-term pathogen
specific memory response. While persistent memory T cells certainly impact the immune …
specific memory response. While persistent memory T cells certainly impact the immune …
Host-directed therapies for cutaneous leishmaniasis
Cutaneous leishmaniasis exhibits a wide spectrum of clinical presentations from self-
resolving infections to severe chronic disease. Anti-parasitic drugs are often ineffective in the …
resolving infections to severe chronic disease. Anti-parasitic drugs are often ineffective in the …
Tegumentary leishmaniasis and coinfections other than HIV
DY Martínez, K Verdonck, PM Kaye… - PLoS neglected …, 2018 - journals.plos.org
Background Tegumentary leishmaniasis (TL) is a disease of skin and/or mucosal tissues
caused by Leishmania parasites. TL patients may concurrently carry other pathogens, which …
caused by Leishmania parasites. TL patients may concurrently carry other pathogens, which …
CD3+ CD4 neg CD8 neg (double negative) T lymphocytes and NKT cells as the main cytotoxic-related-CD107a+ cells in lesions of cutaneous leishmaniasis caused …
R Ferraz, CF Cunha, MIF Pimentel, MR Lyra… - Parasites & …, 2017 - Springer
Background Cutaneous leishmaniasis (CL) is caused by Leishmania (Viannia) braziliensis,
which infects dermal macrophages and dendritic cells, causing an intense immune …
which infects dermal macrophages and dendritic cells, causing an intense immune …
Tracking antigen‐specific CD4+ T cells throughout the course of chronic Leishmania major infection in resistant mice
Primary Leishmania major infection typically produces cutaneous lesions that not only heal
but also harbor persistent parasites. While the opposing roles of CD4+ T‐cell‐derived IFN‐γ …
but also harbor persistent parasites. While the opposing roles of CD4+ T‐cell‐derived IFN‐γ …