Molecular targets for components of essential oils in the insect nervous system—a review
Essential oils (EOs) are lipophilic secondary metabolites obtained from plants; terpenoids
represent the main components of them. A lot of studies showed neurotoxic actions of EOs …
represent the main components of them. A lot of studies showed neurotoxic actions of EOs …
GABAA receptor: Positive and negative allosteric modulators
RW Olsen - Neuropharmacology, 2018 - Elsevier
Abstract gamma-Aminobutyric acid (GABA)-mediated inhibitory neurotransmission and the
gene products involved were discovered during the mid-twentieth century. Historically …
gene products involved were discovered during the mid-twentieth century. Historically …
Shared structural mechanisms of general anaesthetics and benzodiazepines
Most general anaesthetics and classical benzodiazepine drugs act through positive
modulation of γ-aminobutyric acid type A (GABAA) receptors to dampen neuronal activity in …
modulation of γ-aminobutyric acid type A (GABAA) receptors to dampen neuronal activity in …
Towards a comprehensive understanding of anesthetic mechanisms of action: a decade of discovery
Significant progress has been made in the 21st century towards a comprehensive
understanding of the mechanisms of action of general anesthetics, coincident with progress …
understanding of the mechanisms of action of general anesthetics, coincident with progress …
Allosteric modulation of GABAA receptors via multiple drug-binding sites
W Sieghart - Advances in pharmacology, 2015 - Elsevier
GABA A receptors are ligand-gated ion channels composed of five subunits that can be
opened by GABA and be modulated by multiple pharmacologically and clinically important …
opened by GABA and be modulated by multiple pharmacologically and clinically important …
GABAA receptors and the diversity in their structure and pharmacology
Abstract GABA A receptors (GABA A Rs) are a class of ligand-gated ion channels with high
physiological and therapeutic significance. In the brain, these pentameric receptors occur …
physiological and therapeutic significance. In the brain, these pentameric receptors occur …
Multiple functional neurosteroid binding sites on GABAA receptors
ZW Chen, JR Bracamontes, MM Budelier… - PLoS …, 2019 - journals.plos.org
Neurosteroids are endogenous modulators of neuronal excitability and nervous system
development and are being developed as anesthetic agents and treatments for psychiatric …
development and are being developed as anesthetic agents and treatments for psychiatric …
Structural Studies of GABAA Receptor Binding Sites: Which Experimental Structure Tells us What?
R Puthenkalam, M Hieckel, X Simeone… - Frontiers in molecular …, 2016 - frontiersin.org
Atomic resolution structures of cys-loop receptors, including one of a γ-aminobutyric acid
type A receptor (GABAA receptor) subtype, allow amazing insights into the structural …
type A receptor (GABAA receptor) subtype, allow amazing insights into the structural …
Structural basis of neurosteroid anesthetic action on GABAA receptors
Type A γ-aminobutyric acid receptors (GABAARs) are inhibitory pentameric ligand-gated ion
channels in the brain. Many anesthetics and neurosteroids act through binding to the …
channels in the brain. Many anesthetics and neurosteroids act through binding to the …
Allosteric ligands and their binding sites define γ-aminobutyric acid (GABA) type A receptor subtypes
RW Olsen - Advances in Pharmacology, 2015 - Elsevier
Abstract GABA A receptors (GABA A Rs) mediate rapid inhibitory transmission in the brain.
GABA A Rs are ligand-gated chloride ion channel proteins and exist in about a dozen or …
GABA A Rs are ligand-gated chloride ion channel proteins and exist in about a dozen or …