Mitochondria are ubiquitous intracellular organelles found in almost all eukaryotes and
involved in various aspects of cellular life, with a primary role in energy production. The …

Driver mutations in oncogenic pathways, rewiring of cellular metabolism and altered ROS
homoeostasis are intimately connected hallmarks of cancer. Electrons derived from different …

Abstract Complex I (NADH dehydrogenase, NDU) and complex IV (cytochrome-c-oxidase,
COX) of the mitochondrial electron transport chain have been implicated in the …

Parkinson's disease (PD) is known as a mitochondrial disease. Some even regarded it
specifically as a disorder of the complex I of the electron transport chain (ETC). The ETC is …

Respiratory complex I is a~ 1-MDa proton pump in mitochondria. Its structure has been
revealed in great detail, but the structural basis of its assembly, in humans involving at least …

Abstract Sporadic Parkinson's Disease (sPD) is a progressive neurodegenerative disorder
caused by multiple genetic and environmental factors. Mitochondrial dysfunction is one …

Cancer cells reprogram their metabolism to meet bioenergetics and biosynthetic demands.
The first observation of metabolic reprogramming in cancer cells was made a century ago …

The NAD+-dependent deacetylase protein Sirtuin 3 (SIRT3) is emerging among the factors
playing a key role in the regulation of mitochondrial function and in the prevention of …

Cysteine (Cys) plays significant roles in many physiological processes, although its normal
concentration is maintained at the micromole level. Abnormally high levels of intracellular …

Mitochondrial respiration (oxidative phosphorylation, OXPHOS) is an emerging target in
currently refractory cancers such as pancreatic ductal adenocarcinoma (PDAC). However …