Microbial antioxidant defense enzymes

C Staerck, A Gastebois, P Vandeputte, A Calenda… - Microbial …, 2017 - Elsevier
Free radicals are often described as chemical compounds characterized by unpaired
electrons in their outer orbital rendering them highly reactive species. In mammalians …

Comparative Pathobiology of the Intestinal Protozoan Parasites Giardia lamblia, Entamoeba histolytica, and Cryptosporidium parvum

A Hemphill, N Müller, J Müller - Pathogens, 2019 - mdpi.com
Protozoan parasites can infect the human intestinal tract causing serious diseases. In the
following article, we focused on the three most prominent intestinal protozoan pathogens …

Flavonoids as a Natural Treatment Against Entamoeba histolytica

M Martínez-Castillo, J Pacheco-Yepez… - Frontiers in cellular …, 2018 - frontiersin.org
Over the past 20 years, gastrointestinal infections in developing countries have been a
serious health problem and are the second leading cause of morbidity among all age …

X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action

D Parsonage, F Sheng, K Hirata, A Debnath… - Journal of structural …, 2016 - Elsevier
The anti-arthritic gold-containing drug Auranofin is lethal to the protozoan intestinal parasite
Entamoeba histolytica, the causative agent of human amebiasis, in both culture and animal …

New drug target in protozoan parasites: the role of thioredoxin reductase

RM Andrade, SL Reed - Frontiers in microbiology, 2015 - frontiersin.org
Amebiasis causes approximately 70,000 deaths annually and is the third cause of death due
to parasites worldwide. It is treated primarily with metronidazole, which has adverse side …

[HTML][HTML] Entamoeba thiol-based redox metabolism: A potential target for drug development

G Jeelani, T Nozaki - Molecular and biochemical parasitology, 2016 - Elsevier
Amebiasis is an intestinal infection widespread throughout the world caused by the human
pathogen Entamoeba histolytica. Metronidazole has been a drug of choice against …

Thiazolidin-4-one-based derivatives–Efficient tools for designing antiprotozoal agents. A review of the last decade

H Tuszewska, J Szczepański, S Mandziuk… - Bioorganic Chemistry, 2023 - Elsevier
Thiazolidin-4-one derivatives have a wide range of therapeutic implementations and clinical
significance for medicinal chemistry. This heterocyclic ring has been reported to possess a …

Riluzole, a Derivative of Benzothiazole as a Potential Anti-Amoebic Agent against Entamoeba histolytica

M Velásquez-Torres, JG Trujillo-Ferrara… - Pharmaceuticals, 2023 - mdpi.com
Amoebiasis is produced by the parasite Entamoeba histolytica; this disease affects millions
of people throughout the world who may suffer from amoebic colitis or amoebic liver …

In-silico prediction and modeling of the Entamoeba histolytica proteins: Serine-rich Entamoeba histolytica protein and 29 kDa Cysteine-rich protease

K Manochitra, SC Parija - PeerJ, 2017 - peerj.com
Background Amoebiasis is the third most common parasitic cause of morbidity and mortality,
particularly in countries with poor hygienic settings. There exists an ambiguity in the …

Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX

S Brogi, A Fiorillo, G Chemi, S Butini, M Lalle… - European Journal of …, 2017 - Elsevier
Giardia duodenalis is a microaerophilic parasite that colonizes the upper portions of the
small intestine of humans. Giardia infection is a major contributor to diarrheal disease …