Current methods of post-translational modification analysis and their applications in blood cancers

K Dunphy, P Dowling, D Bazou, P O'Gorman - Cancers, 2021 - mdpi.com
Simple Summary This review discusses current techniques used to study post-translational
protein modifications (PTMs) and their contribution to blood cancer research. Blood cancer …

Phosphoproteomics for the masses

PA Grimsrud, DL Swaney, CD Wenger… - ACS chemical …, 2010 - ACS Publications
Protein phosphorylation serves as a primary mechanism of signal transduction in the cells of
biological organisms. Technical advancements over the last several years in mass …

6.12 mass spectrometry for natural product discovery

KB Louie, SM Kosina, Y Hu, H Otani… - … natural products III …, 2020 - books.google.com
6.12. 5.1. 2 APCI 278 6.12. 5.1. 3 DESI 279 6.12. 5.1. 4 MALDI 279 6.12. 5.1. 5 SALDI 280
6.12. 5.2 Mass Analyzers 280 6.12. 5.2. 1 Quadrupole 280 6.12. 5.2. 2 Ion trap 280 6.12. 5.2 …

Chloramphenicol biosynthesis: the structure of CmlS, a flavin-dependent halogenase showing a covalent flavin–aspartate bond

K Podzelinska, R Latimer, A Bhattacharya… - Journal of molecular …, 2010 - Elsevier
Chloramphenicol is a halogenated natural product bearing an unusual dichloroacetyl moiety
that is critical for its antibiotic activity. The operon for chloramphenicol biosynthesis in …

Overview of peptide and protein analysis by mass spectrometry

G Zhang, RS Annan, SA Carr… - Current protocols in …, 2010 - Wiley Online Library
Mass spectrometry is an indispensable tool for peptide and protein analysis owing to its
speed, sensitivity, and versatility. It can be used to determine amino acid sequences of …

Determinants for activation of the atypical AGC kinase Greatwall during M phase entry

KA Blake-Hodek, BC Williams, Y Zhao… - … and cellular biology, 2012 - Taylor & Francis
The atypical AGC kinase Greatwall (Gwl) mediates a pathway that prevents the precocious
removal of phosphorylations added to target proteins by M phase-promoting factor (MPF); …

Identification, quantification, and site localization of protein posttranslational modifications via mass spectrometry-based proteomics

M Ke, H Shen, L Wang, S Luo, L Lin, J Yang… - … preparation, analysis and …, 2016 - Springer
Posttranslational modifications (PTMs) are important biochemical processes for regulating
various signaling pathways and determining specific cell fate. Mass spectrometry (MS) …

A new type of metal chelate affinity chromatography using trivalent lanthanide ions for phosphopeptide enrichment

MR Mirza, M Rainer, CB Messner, Y Güzel… - Analyst, 2013 - pubs.rsc.org
In this study, a new type of immobilized metal-ion affinity chromatography (IMAC) resin for
the isolation of phosphopeptides was synthesized which is based on the specific interaction …

[图书][B] Hydrophilic interaction liquid chromatography (HILIC) and advanced applications

PG Wang, W He - 2011 - books.google.com
This is the first book that comprehensively and systematically describes the new technology
of hydrophilic interaction liquid chromatography (HILIC). Hydrophilic interaction …

Global ion suppression limits the potential of mass spectrometry based phosphoproteomics

RF Dreier, E Ahrné, P Broz… - Journal of proteome …, 2018 - ACS Publications
Mass spectrometry based proteomics has become the method of choice for pinpointing and
monitoring thousands of post-translational modifications, predominately phosphorylation …