Osteoarthritis (OA) is an age-related cartilage degenerative disease, and chondrocyte
senescence has been extensively studied in recent years. Increased numbers of senescent …

Fatty liver diseases, which are commonly associated with high-fat/calorie diet, heavy alcohol
consumption and/or other metabolic disorder causes, lead to serious medical concerns …

Non-alcoholic fatty liver disease (NAFLD) and-steatohepatitis (NASH) imply a state of
excessive fat built-up in livers with/or without inflammation and have led to serious medical …

Abstract Sirtuin 1 (SIRT1) is a prototype mammalian NAD (+)-dependent protein deacetylase
that has emerged as a key metabolic sensor in various metabolic tissues. Growing evidence …

Objective Augmenting nicotinamide adenine dinucleotide (NAD+) metabolism through
dietary provision of NAD+ precursor vitamins translates to improved glucose handling in …

Metabolic dysfunction–associated fatty liver disease (MAFLD) has increasingly become a
significant and highly prevalent cause of chronic liver disease, displaying a wide array of risk …

The rising incidence of type 2 diabetes mellitus (T2DM) is a major public health problem in
industrialized countries, and new therapeutic strategies to prevent T2DM are urgently …

Aims/hypothesis Downregulation of levels of endothelial progenitor cells (EPCs) during in-
vitro short-term exposure to high glucose concentrations relates to reduced activity of silent …

Background Berberine effectively alleviates non-alcoholic fatty liver disease (NAFLD).
Nevertheless, the mechanism is incompletely comprehended. It has been reported that …

Significance: Sirtuins are an evolutionarily conserved family of NAD+-dependent lysine
deacylases and ADP ribosylases. Their requirement for NAD+ as a cosubstrate allows them …