Fragment‐based drug design (FBDD) is a promising approach for the discovery and
optimization of lead compounds. Despite its successes, FBDD also faces some internal …

The concept of privileged structures/substructures (PS) is the idea that certain structural
features produce biological effects more often than others. The PS method can be seen as …

Background G protein-coupled receptors (GPCRs) represent a family of well-characterized
drug targets with significant therapeutic value. Phylogenetic classifications may help to …

In this study, we conducted frequent substructure mining to identify structural features that
discriminate between ligands that do bind to G protein-coupled receptors (GPCRs) and …

Frequent subgraph mining algorithms are widely used in various areas for information
analysis. As yet, a handful of algorithms have been proposed and defined in the literature …

Fragment-based drug design (FBDD) is a promising approach for drug discovery.
Experimental FBDD faces some intrinsic limitations and challenges such as the high …

G protein-coupled receptors (GPCRs) represent a family of well-characterized drug targets
with significant therapeutic value. Phylogenetic classifications may help to understand the …

The discovery of new and better drugs is a costly and slow process in which the
identification of optimal preclinical candidates is often a difficult task. To overcome this …

Celem niniejszej pracy było projektowanie oraz synteza nowych tiosemikarbazonów o
potencjalnych właściwościach przeciwnowotworowych, przeciwbakteryjnych i …

G protein-coupled receptors (GPCRs) represent a family of well-characterized drug targets
with significant therapeutic value. Phylogenetic classifications may help to understand the …