Peroxisome proliferator‐activated receptor‐γ coactivator (PGC)‐1α is a transcriptional
coactivator described as a master regulator of mitochondrial biogenesis and function …

Background: Limb muscle dysfunction is prevalent in chronic obstructive pulmonary disease
(COPD) and it has important clinical implications, such as reduced exercise tolerance …

Aging is the most prominent risk factor for late-onset Alzheimer's disease. Aging associates
with a chronic inflammatory state both in the periphery and in the central nervous system, the …

Experimental evidence supports an intricate association between inflammation and
mitochondrial dysfunction as main contributors of neurological diseases. Inflammatory …

The ubiquitin–proteasome system (UPS) is the main regulatory mechanism of protein
degradation in skeletal muscle. The ubiquitin-ligase enzymes (E3s) have a central role in …

Smoking is the most important risk factor for the development of chronic obstructive
pulmonary disease (COPD). Patients with COPD commonly suffer from skeletal muscle …

Skeletal muscle wasting occurs in a variety of diseases including diabetes, cancer, Crohn's
disease, chronic obstructive pulmonary disease (COPD), disuse, and denervation. Tumor …

Skeletal muscle provides a fundamental basis for human function, enabling locomotion and
respiration. Muscle loss occurs as a consequence of several chronic diseases (cachexia) …

Background Bipolar disorder phenomenologically is a biphasic disorder of energy
availability; increased in mania and decreased in depression. In consort, there is …

COPD (chronic obstructive pulmonary disease) is a major incurable global health burden
and will become the third largest cause of death in the world by 2020. It is currently believed …