Migration of leukocytes is essential for the induction, maintenance, and regulation of
immune responses. On their trafficking routes, leukocytes encounter microenvironments of …

Cells are equipped with asymmetrically localised and functionally specialised components,
including cytoskeletal structures and organelles. Positioning these components to specific …

We present an oblique plane microscope (OPM) that uses a bespoke glass-tipped tertiary
objective to improve the resolution, field of view, and usability over previous variants. Owing …

The immune system provides our defense against pathogens and aberrant cells, including
tumorigenic and infected cells. Motility is one of the fundamental characteristics that enable …

The role of Pannexin (PANX) channels during collective and single cell migration is
increasingly recognized. Amongst many functions that are relevant to cell migration, here we …

The stiffness and topography of a cell's extracellular matrix (ECM) are physical cues that
play a key role in regulating processes that determine cellular fate and function. While …

Simple Summary Various microbial pathogens target the actin-binding protein cortactin to
promote their own uptake, proliferation and spread, and exhibit proposed roles in human …

Cell migration is a fundamental and functional cellular process, influenced by a complex
microenvironment consisting of different cells and extracellular matrix. Recent research has …

Immune cells are constantly on the move through multicellular organisms to explore and
respond to pathogens and other harmful insults. While moving, immune cells efficiently …

Physical constraints, such as compression, shear stress, stretching and tension, play major
roles during development, tissue homeostasis, immune responses and pathologies. Cells …