The glaucomas are a group of conditions leading to irreversible sight loss and characterised
by progressive loss of retinal ganglion cells. Although not always elevated, intraocular …

Glaucoma is a term describing a group of ocular disorders with multi‐factorial etiology united
by a clinically characteristic intraocular pressure‐associated optic neuropathy. It is not a …

Glaucoma is a neurodegenerative disease that features the death of retinal ganglion cells
(RGCs) in the retina, often as a result of prolonged increases in intraocular pressure. We …

Primary open-angle glaucoma is a progressive optic neuropathy and, perhaps, the most
common form of glaucoma. Because the disease is treatable, and because the visual …

For many retinal diseases, including age-related macular degeneration (AMD), glaucoma,
and diabetic retinopathy (DR), the exact pathogenesis is still unclear. Moreover, the currently …

Glaucoma is recognized to have its major detrimental effect upon the eye by killing retinal
ganglion cells. The process of cell death appears to be initiated at the optic nerve head …

purpose. To determine whether acute experimental glaucoma in rats obstructs retrograde
transport of brain-derived neurotrophic factor (BDNF) to retinal ganglion cells (RGCs) …

purpose. In both animal model systems and in human glaucoma, retinal ganglion cells
(RGCs) die by apoptosis. To understand how RGC apoptosis is initiated in these systems …

Nerve growth factor (NGF) is the firstly discovered and best characterized neurotrophic
factor, known to play a critical protective role in the development and survival of sympathetic …

Glaucoma is a common optic neuropathy with a complex etiology often linked to sensitivity to
intraocular pressure. Though the precise mechanisms that mediate or transduce this …