Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer's disease: review, recommendation, implementation and application
Alzheimer's disease (AD) is the most common form of dementia, characterized by
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …
Single-cell network biology for resolving cellular heterogeneity in human diseases
Understanding cellular heterogeneity is the holy grail of biology and medicine. Cells
harboring identical genomes show a wide variety of behaviors in multicellular organisms …
harboring identical genomes show a wide variety of behaviors in multicellular organisms …
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
Although cellular senescence drives multiple age-related co-morbidities through the
senescence-associated secretory phenotype, in vivo senescent cell identification remains …
senescence-associated secretory phenotype, in vivo senescent cell identification remains …
Single-cell biological network inference using a heterogeneous graph transformer
Single-cell multi-omics (scMulti-omics) allows the quantification of multiple modalities
simultaneously to capture the intricacy of complex molecular mechanisms and cellular …
simultaneously to capture the intricacy of complex molecular mechanisms and cellular …
Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis
We provide a single-cell atlas of idiopathic pulmonary fibrosis (IPF), a fatal interstitial lung
disease, by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 …
disease, by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 …
[HTML][HTML] Platelet-instructed SPP1+ macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner
Fibrosis represents the common end stage of chronic organ injury independent of the initial
insult, destroying tissue architecture and driving organ failure. Here we discover a …
insult, destroying tissue architecture and driving organ failure. Here we discover a …
Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche
P Baldominos, A Barbera-Mourelle, O Barreiro… - Cell, 2022 - cell.com
Immunotherapy is a promising treatment for triple-negative breast cancer (TNBC), but
patients relapse, highlighting the need to understand the mechanisms of resistance. We …
patients relapse, highlighting the need to understand the mechanisms of resistance. We …
Spatial Transcriptomics-correlated Electron Microscopy maps transcriptional and ultrastructural responses to brain injury
P Androvic, M Schifferer, K Perez Anderson… - Nature …, 2023 - nature.com
Understanding the complexity of cellular function within a tissue necessitates the
combination of multiple phenotypic readouts. Here, we developed a method that links …
combination of multiple phenotypic readouts. Here, we developed a method that links …
Brassinosteroid gene regulatory networks at cellular resolution in the Arabidopsis root
Brassinosteroids are plant steroid hormones that regulate diverse processes, such as cell
division and cell elongation, through gene regulatory networks that vary in space and time …
division and cell elongation, through gene regulatory networks that vary in space and time …
The single-cell eQTLGen consortium
In recent years, functional genomics approaches combining genetic information with bulk
RNA-sequencing data have identified the downstream expression effects of disease …
RNA-sequencing data have identified the downstream expression effects of disease …