Matrix metalloproteinases (MMPs) are physiologically expressed in the central nervous
system in neurons, astrocytes and microglia, and their aberrant elevation contributes to a …

During the last decade, multiple data have been obtained, pointing to an involvement of
extracellular, including extrasynaptic, proteolysis in epilepsy pathogenesis. The most …

Major depressive disorder (MDD) is a prevalent psychiatric disorder, and exposure to stress
is a robust risk factor for MDD. Clinical data and rodent models have indicated the negative …

BACKGROUND: Matrix metalloproteinase-9 (MMP-9) is an enzyme implicated in a number
of pathological conditions such as cardiovascular disease, cancer, and neuropsychiatric …

Background: Fluoxetine, a selective serotonin reuptake inhibitor, has been found recently to
possess anti‐inflammatory properties. The present study investigates the effects of fluoxetine …

Selective reuptake inhibitors (SSRIs), such as fluoxetine and sertraline, increase circulating
Transforming-Growth-Factor-β1 (TGF-β1) levels in depressed patients, and are currently …

Focal cortical dysplasia (FCD) is a developmental brain disorder characterized by localized
abnormalities of cortical layering and neuronal morphology. It is associated with …

Major depressive disorder is a highly prevalent psychiatric condition. Metalloproteinase 9
(MMP-9), a gelatinase involved in synaptic plasticity, learning and memory processes, is …

Aim: To investigate the effects of the selective serotonin reuptake inhibitor (SSRI) fluoxetine
on extracellular matrix (ECM) remodeling of the pulmonary artery and inflammation of the …

Background Electroconvulsive seizure therapy is often used in both treatment-resistant and
geriatric depression. However, preclinical studies identifying targets of chronic …