The study of genes mutated in human disease often leads to new insights into biology as
well as disease mechanisms. One such gene is Wilms' tumour 1 (WT1), which plays multiple …

Molecules that can specifically silence gene expression are powerful research tools. Much
effort has been put into the development of such molecules and has resulted in the creation …

Congenital abnormalities of the kidney and urinary tract (CAKUT) occur in 1 out of 500
newborns, and constitute approximately 20–30% of all anomalies identified in the prenatal …

Over the years, many apparently contradictory findings and functions have been ascribed to
the protein product of the WT1 tumour suppressor gene. These include being a …

Wilms' tumour, or nephroblastoma, is a common childhood tumour that is intimately linked to
early kidney development and is often associated with persistent embryonic renal tissue and …

RNA interference (RNAi) is now an umbrella term referring to post-transcriptional gene
silencing mediated by either degradation or translation arrest of target RNA. This process is …

Populations of self-renewing cells that arise during normal embryonic development harbour
the potential for rapid proliferation, migration or transdifferentiation and, therefore, tumour …

Genes identified as being mutated in Wilms' tumour include TP53, a classic tumour
suppressor gene (TSG); CTNNB1 (encoding β-catenin), a classic oncogene; WTX, which …

The Wilms tumor protein WT1 is an essential factor for kidney development. In humans,
mutations in WT1 lead to Wilms tumor, a pediatric kidney cancer as well as to developmental …

Here we describe a novel method in which embryonic kidneys are dissociated into single-
cell suspensions and then reaggregated to form organotypic renal structures. Kidney cell …