Simple Summary This review discusses the heterogeneity of breast cancer and strategies to
understand it using multi-omics profiling methods at the traditional bulk and single-cell …

Background Although numerous mouse models of breast carcinomas have been developed,
we do not know the extent to which any faithfully represent clinically significant human …

Background The epidermal growth factor receptor (EGFR/HER1) and its downstream
signaling events are important for regulating cell growth and behavior in many epithelial …

Advances in the screening of new therapeutic options have significantly reduced the breast
cancer death rate over the last decade. Despite these advances, breast cancer remains the …

Insulin-like growth factors (IGFs) play a crucial role in regulating cell proliferation and
differentiation. The aim of this study was to examine the potential relationship between …

Purpose: Anticancer drug development is inefficient, but genetically engineered murine
models (GEMM) and orthotopic, syngeneic transplants (OST) of cancer may offer …

Background Oncogene overexpression in primary cells often triggers the induction of a
cellular safeguard response promoting senescence or apoptosis. Secondary cooperating …

The effects of lovastatin, a potent inhibitor of HMG CoA reductase, on experimental
mammary and prostate oncogenesis, were studied in vitro and in vivo. Lovastatin inhibited …

Female transgenic mice that express SV40 T/t antigens under the regulatory control of the
rat C3 (1) gene spontaneously develop multifocal mammary lesions that predictably evolve …

Active Ras proteins contribute to breast carcinogenesis and progression. Here, we provide
evidence that active H-Ras regulates the expression and activity of the E2F family of …