Genetic variation in microRNA networks: the implications for cancer research
Many studies have highlighted the role that microRNAs have in physiological processes and
how their deregulation can lead to cancer. More recently, it has been proposed that the …
how their deregulation can lead to cancer. More recently, it has been proposed that the …
The let-7 family of microRNAs
S Roush, FJ Slack - Trends in cell biology, 2008 - cell.com
The first two known microRNAs (miRNAs), lin-4 and let-7, were originally discovered in the
nematode Caenorhabditis elegans and control the timing of stem-cell division and …
nematode Caenorhabditis elegans and control the timing of stem-cell division and …
Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome
RNA editing is a post-transcriptional event that recodes hereditary information. Here we
describe a comprehensive profile of the RNA editome of a male Han Chinese individual …
describe a comprehensive profile of the RNA editome of a male Han Chinese individual …
Applications of new sequencing technologies for transcriptome analysis
Transcriptome analysis has been a key area of biological inquiry for decades. Over the
years, research in the field has progressed from candidate gene-based detection of RNAs …
years, research in the field has progressed from candidate gene-based detection of RNAs …
MicroRNAs and their isomiRs function cooperatively to target common biological pathways
N Cloonan, S Wani, Q Xu, J Gu, K Lea, S Heater… - Genome biology, 2011 - Springer
Abstract Background Variants of microRNAs (miRNAs), called isomiRs, are commonly
reported in deep-sequencing studies; however, the functional significance of these variants …
reported in deep-sequencing studies; however, the functional significance of these variants …
The deep evolution of metazoan microRNAs
BM Wheeler, AM Heimberg, VN Moy… - Evolution & …, 2009 - Wiley Online Library
SUMMARY microRNAs (miRNAs) are approximately 22‐nucleotide noncoding RNA
regulatory genes that are key players in cellular differentiation and homeostasis. They might …
regulatory genes that are key players in cellular differentiation and homeostasis. They might …
Accurate identification of A-to-I RNA editing in human by transcriptome sequencing
RNA editing enhances the diversity of gene products at the post-transcriptional level.
Approaches for genome-wide identification of RNA editing face two main challenges …
Approaches for genome-wide identification of RNA editing face two main challenges …
A myriad of miRNA variants in control and Huntington's disease brain regions detected by massively parallel sequencing
Huntington disease (HD) is a neurodegenerative disorder that predominantly affects
neurons of the forebrain. We have applied the Illumina massively parallel sequencing to …
neurons of the forebrain. We have applied the Illumina massively parallel sequencing to …
The repertoire and features of human platelet microRNAs
H Plé, P Landry, A Benham, C Coarfa, PH Gunaratne… - PloS one, 2012 - journals.plos.org
Playing a central role in the maintenance of hemostasis as well as in thrombotic disorders,
platelets contain a relatively diverse messenger RNA (mRNA) transcriptome as well as …
platelets contain a relatively diverse messenger RNA (mRNA) transcriptome as well as …
An antagomir to microRNA Let7f promotes neuroprotection in an ischemic stroke model
A Selvamani, P Sathyan, RC Miranda, F Sohrabji - PloS one, 2012 - journals.plos.org
We previously showed that middle-aged female rats sustain a larger infarct following
experimental stroke as compared to younger female rats, and paradoxically, estrogen …
experimental stroke as compared to younger female rats, and paradoxically, estrogen …