Click chemistry-aided drug discovery: A retrospective and prospective outlook
R Zhao, J Zhu, X Jiang, R Bai - European Journal of Medicinal Chemistry, 2024 - Elsevier
Click chemistry has emerged as a valuable tool for rapid compound synthesis, presenting
notable advantages and convenience in the exploration of potential drug candidates. In …
notable advantages and convenience in the exploration of potential drug candidates. In …
[HTML][HTML] New Therapies and Strategies to Curb HIV Infections with a Focus on Macrophages and Reservoirs
M Marra, A Catalano, MS Sinicropi, J Ceramella… - Viruses, 2024 - mdpi.com
More than 80 million people worldwide have been infected with the human
immunodeficiency virus (HIV). There are now approximately 39 million individuals living with …
immunodeficiency virus (HIV). There are now approximately 39 million individuals living with …
[HTML][HTML] Global Transcriptomic Analysis of Topical Sodium Alginate Protection against Peptic Damage in an In Vitro Model of Treatment-Resistant Gastroesophageal …
Breakthrough symptoms are thought to occur in roughly half of all gastroesophageal reflux
disease (GERD) patients despite maximal acid suppression (proton pump inhibitor, PPI) …
disease (GERD) patients despite maximal acid suppression (proton pump inhibitor, PPI) …
Advances in laryngopharyngeal reflux: Etiology, diagnosis, and management
TL Samuels, J Aoun, I Husain… - Annals of the New …, 2024 - Wiley Online Library
Laryngopharyngeal reflux (LPR) manifests as a variety of nonspecific upper aerodigestive
tract symptoms. Rather than a single disorder, LPR may be conceived of as a spectrum of …
tract symptoms. Rather than a single disorder, LPR may be conceived of as a spectrum of …
Amprenavir inhibits pepsin‐mediated laryngeal epithelial disruption and E‐cadherin cleavage in vitro
TL Samuels, S Blaine‐Sauer, K Yan… - Laryngoscope …, 2023 - Wiley Online Library
Background Laryngopharyngeal reflux (LPR) causes chronic cough, throat clearing,
hoarseness, and dysphagia and can promote laryngeal carcinogenesis. More than 20% of …
hoarseness, and dysphagia and can promote laryngeal carcinogenesis. More than 20% of …
Identification of genome-wide copy number variation-driven subtypes for the treatment and prognostic prediction of esophageal carcinoma
C Zhao, H Han, Y Tian, G Qu, Y Xu, Y Wang, L Shi - Heliyon, 2024 - cell.com
Background Esophageal carcinoma (ESCA) is a frequently detected gastrointestinal cancer.
Copy number variants (CNVs) have a dramatic impact on the screening, diagnosis and …
Copy number variants (CNVs) have a dramatic impact on the screening, diagnosis and …
Sustained-Release Oral Fosamprenavir Formulation for Treatment of Reflux
N Johnston, FG Vigile - US Patent App. 18/361,201, 2024 - Google Patents
MLBVMOWEQCZNCC-OEMFJLHTSA-N fosamprenavir Chemical compound C ([C@@
H]([C@ H](OP (O)(O)= O) CN (CC (C) C) S (= O)(= O) C= 1C= CC (N)= CC= 1) NC (= O) O …
H]([C@ H](OP (O)(O)= O) CN (CC (C) C) S (= O)(= O) C= 1C= CC (N)= CC= 1) NC (= O) O …