Ruminants have a semi-invasive placenta, which possess highly vascularized placentomes
formed by maternal endometrial caruncles and fetal placental cotyledons and required for …

Early placenta development involves cytotrophoblast differentiation into extravillous
trophoblast (EVT) and syncytiotrophoblast (STB). Defective trophoblast development and …

In contrast to rodents, the mechanisms underlying human trophectoderm and early placenta
specification are understudied due to ethical barriers and the scarcity of embryos. Recent …

With the development of the embryo, the totipotent blastomere undergoes the first lineage
decision to the inner cell mass (ICM) and the trophectoderm (TE). The ICM forms the fetus …

Background Extravillous trophoblast cell (EVT) differentiation and its communication with
maternal decidua especially the leading immune cell type natural killer (NK) cell are critical …

For over a century after their discovery astrocytes were regarded merely as cells located
among other brain cells to hold and give support to neurons. Astrocytes …

A central determinant of pregnancy success is proper development of the conceptus
(embryo/fetus and associated extraembryonic membranes including the placenta). Although …

Failures in growth and differentiation of the early human placenta are associated with severe
pregnancy disorders such as pre-eclampsia and fetal growth restriction. However, regulatory …

The placenta performs essential biologic functions for fetal development throughout
pregnancy. Placental dysfunction is at the root of multiple adverse birth outcomes such as …

The placenta is the critical interface between mother and fetus, and consequently, placental
dysfunction underlies many pregnancy complications. Placental formation requires an …