Omicron: what makes the latest SARS-CoV-2 variant of concern so concerning?
Emerging strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the
causative agent of the coronavirus disease 2019 (COVID-19) pandemic, that show …
causative agent of the coronavirus disease 2019 (COVID-19) pandemic, that show …
The human virome: assembly, composition and host interactions
G Liang, FD Bushman - Nature Reviews Microbiology, 2021 - nature.com
The human body hosts vast microbial communities, termed the microbiome. Less well
known is the fact that the human body also hosts vast numbers of different viruses …
known is the fact that the human body also hosts vast numbers of different viruses …
Global landscape of SARS-CoV-2 genomic surveillance and data sharing
Genomic surveillance has shaped our understanding of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) variants. We performed a global landscape analysis on SARS …
coronavirus 2 (SARS-CoV-2) variants. We performed a global landscape analysis on SARS …
Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa
The SARS-CoV-2 epidemic in southern Africa has been characterized by three distinct
waves. The first was associated with a mix of SARS-CoV-2 lineages, while the second and …
waves. The first was associated with a mix of SARS-CoV-2 lineages, while the second and …
[HTML][HTML] Evidence for a mouse origin of the SARS-CoV-2 Omicron variant
C Wei, KJ Shan, W Wang, S Zhang, Q Huan… - Journal of genetics and …, 2021 - Elsevier
The rapid accumulation of mutations in the SARS-CoV-2 Omicron variant that enabled its
outbreak raises questions as to whether its proximal origin occurred in humans or another …
outbreak raises questions as to whether its proximal origin occurred in humans or another …
[HTML][HTML] Phages and their satellites encode hotspots of antiviral systems
Bacteria carry diverse genetic systems to defend against viral infection, some of which are
found within prophages where they inhibit competing viruses. Phage satellites pose …
found within prophages where they inhibit competing viruses. Phage satellites pose …
RESCRIPt: Reproducible sequence taxonomy reference database management
Nucleotide sequence and taxonomy reference databases are critical resources for
widespread applications including marker-gene and metagenome sequencing for …
widespread applications including marker-gene and metagenome sequencing for …
SARS-CoV-2 3CLpro mutations selected in a VSV-based system confer resistance to nirmatrelvir, ensitrelvir, and GC376
E Heilmann, F Costacurta, SA Moghadasi… - Science translational …, 2022 - science.org
Protease inhibitors are among the most powerful antiviral drugs. Nirmatrelvir is the first
protease inhibitor specifically developed against the SARS-CoV-2 protease 3CLpro that has …
protease inhibitor specifically developed against the SARS-CoV-2 protease 3CLpro that has …
A prenylated dsRNA sensor protects against severe COVID-19
INTRODUCTION Interferons (IFNs) are cytokines that are rapidly deployed in response to
invading pathogens. By initiating a signaling cascade that stimulates the expression of …
invading pathogens. By initiating a signaling cascade that stimulates the expression of …
[HTML][HTML] Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites
S Kang, M Yang, Z Hong, L Zhang, Z Huang… - … Pharmaceutica Sinica B, 2020 - Elsevier
The outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 virus continually
lead to worldwide human infections and deaths. Currently, there is no specific viral protein …
lead to worldwide human infections and deaths. Currently, there is no specific viral protein …