Bone is a hard yet dynamic tissue with remarkable healing capacities. Research to date has
greatly advanced the understanding of how bone heals and has led to marked success in …

This review explores state-of-the-art and new perspectives description of scaffold-based
strategies utilized in in-suit bone tissue engineering. The bone defects caused by severe …

Our goal was to generate functionalized 3D-printed scaffolds for bone regeneration using
silk-hydroxyapatite bone cements and osteoinductive, proangiogenic and neurotrophic …

Microvasculature functions at the tissue and cell level, regulating local mass exchange of
oxygen and nutrient-rich blood. While there has been considerable success in the …

Background Bone grafting has been considered the gold standard for hard tissue
reconstructive surgery and is widely used for large mandibular defect reconstruction …

Over the past years, the fabrication of adequate vascular networks has remained the main
challenge in engineering tissues due to technical difficulties, while the ultimate objective of …

Reconstruction of critical-sized bone defects remains a tremendous challenge for surgeons
worldwide. Despite the variety of surgical techniques, current clinical strategies for bone …

Bone substitutes are used in nearly half of all musculoskeletal surgeries. The “gold
standard” graft is an autograft that is limited by supply and site morbidity. Therefore, allograft …

Currently, the fabrication of a functional vascular network to maintain the viability of
engineered tissues is a major bottleneck in the way of developing a more advanced …

Current bioceramic scaffolds for critical-size bone defects are still facing various challenges
such as the poor capability of self-resorption, vascularization and osteogenesis. Herein, a …