The endothelins comprise three structurally similar 21-amino acid peptides. Endothelin-1
and-2 activate two G-protein coupled receptors, ET A and ET B, with equal affinity, whereas …

One of the novel interesting topics in the study of cardiovascular disease is the role of the
oxidation system, since inflammation and oxidative stress are known to lead to …

The endothelin axis, recognized for its vasoconstrictive action, plays a central role in the
pathology of pulmonary arterial hypertension (PAH). Treatment with approved endothelin …

Hypertension and obesity are two significant factors that contribute to the onset and
exacerbation of a cascade of mechanisms including activation of the sympathetic and renin …

Obstructive sleep apnea (OSA) is now recognized as an independent and important risk
factor for cardiovascular diseases such as hypertension, coronary heart disease, heart …

The developmental origins of health and disease theory is based on evidence that a
suboptimal environment during fetal and neonatal development can significantly impact the …

Aims Thrombospondin-1 (TSP1) is a ligand for CD47 and TSP1−/− mice are protected from
pulmonary hypertension (PH). We hypothesized the TSP1–CD47 axis is upregulated in …

Cardiovascular diseases (CVD) constitute the major cause of death worldwide and show a
higher prevalence in the adult population. The human umbilical cord consistsof two arteries …

Background Silibinin is a polyphenolic compound that could modulate estrogen receptor
activation. Vascular dysfunction is considered a key initiator in atherosclerosis and may …

Abstract Endothelin (ET)-1 is implicated in the pathophysiology of cardiovascular diseases
although its role in obesity anomalies has not been fully elucidated. This study was …