Principles of nucleosome recognition by chromatin factors and enzymes
RK McGinty, S Tan - Current Opinion in Structural Biology, 2021 - Elsevier
The recent torrent of structures of chromatin complexes determined by cryoelectron
microscopy provides an opportunity to discern general principles for how chromatin factors …
microscopy provides an opportunity to discern general principles for how chromatin factors …
The emerging role of chromatin remodelers in neurodevelopmental disorders: a developmental perspective
B Mossink, M Negwer, D Schubert… - Cellular and Molecular …, 2021 - Springer
Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …
PRC2 functions in development and congenital disorders
O Deevy, AP Bracken - Development, 2019 - journals.biologists.com
ABSTRACT Polycomb repressive complex 2 (PRC2) is a conserved chromatin regulator that
is responsible for the methylation of histone H3 lysine 27 (H3K27). PRC2 is essential for …
is responsible for the methylation of histone H3 lysine 27 (H3K27). PRC2 is essential for …
Polycomb-dependent histone H2A ubiquitination links developmental disorders with cancer
Cell identity is tightly controlled by specific transcriptional programs which require post-
translational modifications of histones. These histone modifications allow the establishment …
translational modifications of histones. These histone modifications allow the establishment …
USP7 regulates the ncPRC1 Polycomb axis to stimulate genomic H2AK119ub1 deposition uncoupled from H3K27me3
A Sijm, Y Atlasi, JA van der Knaap… - Science …, 2022 - science.org
Ubiquitin-specific protease 7 (USP7) has been implicated in cancer progression and
neurodevelopment. However, its molecular targets remain poorly characterized. We …
neurodevelopment. However, its molecular targets remain poorly characterized. We …
Regulation of p53 by E3s
M Pan, C Blattner - Cancers, 2021 - mdpi.com
Simple Summary The p53 protein is a transcription factor that initiates cell cycle arrest and
apoptosis and by this counteracts tumorigenesis. Because of its anti-proliferative activity …
apoptosis and by this counteracts tumorigenesis. Because of its anti-proliferative activity …
CRISPR-Cas9 human gene replacement and phenomic characterization in Caenorhabditis elegans to understand the functional conservation of human genes and …
Our ability to sequence genomes has vastly surpassed our ability to interpret the genetic
variation we discover. This presents a major challenge in the clinical setting, where the …
variation we discover. This presents a major challenge in the clinical setting, where the …
Polycomb repressive complex 1: Regulators of neurogenesis from embryonic to adult stage
Abstract Development of vertebrate nervous system is a complex process which involves
differential gene expression and disruptions in this process or in the mature brain, may lead …
differential gene expression and disruptions in this process or in the mature brain, may lead …
Rare deleterious de novo missense variants in Rnf2/Ring2 are associated with a neurodevelopmental disorder with unique clinical features
Abstract The Polycomb group (PcG) gene RNF2 (RING2) encodes a catalytic subunit of the
Polycomb repressive complex 1 (PRC1), an evolutionarily conserved machinery that post …
Polycomb repressive complex 1 (PRC1), an evolutionarily conserved machinery that post …
Ubiquitin‐dependent regulation of transcription in development and disease
Transcription is an elaborate process that is required to establish and maintain the identity of
the more than two hundred cell types of a metazoan organism. Strict regulation of gene …
the more than two hundred cell types of a metazoan organism. Strict regulation of gene …