Novel therapeutic approaches targeting the renin-angiotensin system and associated peptides in hypertension and heart failure
LB Arendse, AHJ Danser, M Poglitsch, RM Touyz… - Pharmacological …, 2019 - Elsevier
Despite the success of renin-angiotensin system (RAS) blockade by angiotensin-converting
enzyme (ACE) inhibitors and angiotensin II type 1 receptor (AT 1 R) blockers, current …
enzyme (ACE) inhibitors and angiotensin II type 1 receptor (AT 1 R) blockers, current …
Endothelin
AP Davenport, KA Hyndman, N Dhaun… - Pharmacological …, 2016 - Elsevier
The endothelins comprise three structurally similar 21-amino acid peptides. Endothelin-1
and-2 activate two G-protein coupled receptors, ET A and ET B, with equal affinity, whereas …
and-2 activate two G-protein coupled receptors, ET A and ET B, with equal affinity, whereas …
The lutropin/choriogonadotropin receptor, a 2002 perspective
Reproduction cannot take place without the proper functioning of the lutropin/
choriogonadotropin receptor (LHR). When the LHR does not work properly, ovulation does …
choriogonadotropin receptor (LHR). When the LHR does not work properly, ovulation does …
Regulation of blood pressure and salt homeostasis by endothelin
DE Kohan, NF Rossi, EW Inscho… - Physiological …, 2011 - journals.physiology.org
Endothelin (ET) peptides and their receptors are intimately involved in the physiological
control of systemic blood pressure and body Na homeostasis, exerting these effects through …
control of systemic blood pressure and body Na homeostasis, exerting these effects through …
Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis …
K Kristiansen - Pharmacology & therapeutics, 2004 - Elsevier
The superfamily of G-protein-coupled receptors (GPCRs) could be subclassified into 7
families (A, B, large N-terminal family B-7 transmembrane helix, C, Frizzled/Smoothened …
families (A, B, large N-terminal family B-7 transmembrane helix, C, Frizzled/Smoothened …
Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and ß-arrestin proteins
Sequestration of G protein-coupled receptors from the cell surface is a commonly observed
phenomenon following agonist-stimulation. This process is now believed to be important for …
phenomenon following agonist-stimulation. This process is now believed to be important for …
Activation mechanism of endothelin ETB receptor by endothelin-1
Abstract Endothelin, a 21-amino-acid peptide, participates in various physiological
processes, such as regulation of vascular tone, humoral homeostasis, neural crest cell …
processes, such as regulation of vascular tone, humoral homeostasis, neural crest cell …
[PDF][PDF] G-protein coupled receptors in lipid rafts and caveolae: how, when and why do they go there?
B Chini, M Parenti - Journal of molecular endocrinology, 2004 - researchgate.net
This review describes the advances in our understanding of the role of G-protein coupled
receptor (GPCR) localisation in membrane microdomains known as lipid rafts and caveolae …
receptor (GPCR) localisation in membrane microdomains known as lipid rafts and caveolae …
Contrasting Actions of Endothelin ETA and ETB Receptors in Cardiovascular Disease
MP Schneider, EI Boesen… - Annu. Rev. Pharmacol …, 2007 - annualreviews.org
First identified as a powerful vasoconstrictor, endothelin has an extremely diverse set of
actions that influence homeostatic mechanisms throughout the body. Two receptor subtypes …
actions that influence homeostatic mechanisms throughout the body. Two receptor subtypes …
Cryo-EM structure of the endothelin-1-ETB-Gi complex
FK Sano, H Akasaka, W Shihoya, O Nureki - elife, 2023 - elifesciences.org
The endothelin ET B receptor is a promiscuous G-protein coupled receptor that is activated
by vasoactive peptide endothelins. ET B signaling induces reactive astrocytes in the brain …
by vasoactive peptide endothelins. ET B signaling induces reactive astrocytes in the brain …