Cardiovascular and metabolic diseases (CVMD) are the leading causes of death worldwide,
underscoring the urgent necessity to develop new pharmacotherapies. Berberine (BBR) is …

Obesity has become a worldwide issue and is accompanied by serious complications.
Western high energy diet has been identified to be a major factor contributing to the current …

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a multifactorial
condition characterized by insulin resistance, oxidative stress, chronic low-grade …

Background Obesity is a worldwide problem that resulted from the excessive fat
accumulation in adipose tissue, leading to the impairment of individual health. Mulberry leaf …

Long-term stored oolong tea has recently attracted considerable attention concerning its
salutary effect. In this study, the anti-obesity effect of different years' oolong tea on high-fat …

Neonatal-streptozotocin (n-STZ)-induced diabetes mimics most of the clinicopathological
symptoms of type 2 diabetes mellitus (T2DM) peripheral neuropathy. Berberine, a plant …

Background Consumption of industrially produced trans-fatty acids (iTFAs) can result in
alteration to lipid profile and glucose metabolism. Moreover, a diet high in iTFAs could …

Aim This study is designed to investigate whether or not AMP-activated protein kinase α1
(AMPKα1) is required for natural product berberine (BBR) to improve glucose and lipid …

Clozapine (CLO) remains an ultimate option for patients with treatment resistant
schizophrenia. However, the atypical antipsychotic is often associated with serious …

Obesity is defined as a dampness-heat syndrome in traditional Chinese medicine. Coptidis
Rhizoma is an herb used to clear heat and eliminate dampness in obesity and its …