Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Abstract Purpose of Review Our goal is to examine the processes—both central and
peripheral—that underlie the development of peripherally-induced neuropathic pain (pNP) …

HT plays a crucial role in the progress and adjustment of pain both centrally and
peripherally. The therapeutic action of the 5-HT receptorsagonist and antagonist in …

The association of chronic pain with depression is becoming increasingly recognized.
Treating both the conditions together is essential for an effective treatment outcome. In this …

Chronic primary pain (CPP) is a group of diseases with long‐term pain and functional
disorders but without structural or specific tissue pathologies. CPP is becoming a serious …

5‐hydroxytryptamine (5‐HT; serotonin) is traditionally considered as a key mediator
implicated in migraine. Multiple 5‐HT receptor subtypes contribute to a variety of region …

Chronic pain conditions such as low back pain and osteoarthritis are the most prominent
causes of disability worldwide. Morphine and other opioid drugs are the gold standard …

Earlier studies indicate that the central nucleus of the amygdala (CeA) contributes to
neuropathic pain. Here we studied whether amygdaloid administration of antioxidants or …

The rostral ventromedial medulla (RVM) is a bulbospinal nuclei in the descending pain
modulation system, and directly affects spinal nociceptive transmission through …

Salvia amarissima Ortega is an endemic species of Mexico used in folk medicine to alleviate
pain and as a nervous tranquilizer. The S. amarissima extract and one of its abundant …