Contingent upon concentration, reactive oxygen species (ROS) influence cancer evolution
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …

A variety of targeted anticancer agents have been successfully introduced into clinical
practice, largely reflecting their ability to inhibit specific molecular alterations that are …

NASA's plans for space exploration include a return to the Moon to stay—boots back on the
lunar surface with an orbital outpost. This station will be a launch point for voyages to …

Ionizing radiation causes DNA damage and is a mainstay for cancer treatment, but
understanding of its genomic impact is limited. We analyzed mutational spectra following …

Cancer is driven by genomic mutations in 'cancer driver'genes, which have essential roles in
tumor development. These mutations may be caused by exposure to mutagens in the …

Increased production and buildup of reactive oxygen species (ROS) can lead to various
health issues, including metabolic problems, cancers, and neurological conditions. Our …

The ability to accurately measure mutations is critical for basic research and identifying
potential drug and chemical carcinogens. Current methods for in vivo quantification of …

Context Pituitary corticotroph adenomas are rare tumors that can be associated with excess
adrenocorticotropin (ACTH) and adrenal cortisol production, resulting in the clinically …

Exposure to environmental ionizing radiation is prevalent, with greatest lifetime doses
typically from high Linear Energy Transfer (high-LET) alpha particles via the radioactive …

Initiating from a single cell, cancer undergoes clonal evolution, leading to a high degree of
intratumor heterogeneity (ITH). The arising genetic heterogeneity between cancer cells is …