Inflammatory bowel diseases (IBD) and the microbiome—searching the crime scene for clues

M Lee, EB Chang - Gastroenterology, 2021 - Elsevier
Inflammatory bowel diseases (IBD) develop via convergence of environmental, microbial,
immunological, and genetic factors. Alterations in the gut microbiota have been associated …

Type 2 immunity in the skin and lungs

CA Akdis, PD Arkwright, MC Brüggen, W Busse… - Allergy, 2020 - Wiley Online Library
There has been extensive progress in understanding the cellular and molecular
mechanisms of inflammation and immune regulation in allergic diseases of the skin and …

The intestinal barrier, an arbitrator turned provocateur in IBD

S Mehandru, JF Colombel - Nature Reviews Gastroenterology & …, 2021 - nature.com
Key studies published in 2020 demonstrate that an impaired intestinal barrier precedes
clinical diagnosis of inflammatory bowel disease (IBD) by years. Furthermore, studies …

[HTML][HTML] The role of intestinal permeability in gastrointestinal disorders and current methods of evaluation

T Vanuytsel, J Tack, R Farre - Frontiers in Nutrition, 2021 - frontiersin.org
An increased intestinal permeability has been described in various gastrointestinal and non-
gastrointestinal disorders. Nevertheless, the concept and definition of intestinal permeability …

The intestinal epithelial barrier: a therapeutic target?

MA Odenwald, JR Turner - Nature reviews Gastroenterology & …, 2017 - nature.com
A fundamental function of the intestinal epithelium is to act as a barrier that limits interactions
between luminal contents such as the intestinal microbiota, the underlying immune system …

Environmental factors in epithelial barrier dysfunction

ZC Sözener, L Cevhertas, K Nadeau, M Akdis… - Journal of Allergy and …, 2020 - Elsevier
The main interfaces controlling and attempting to homeostatically balance communications
between the host and the environment are the epithelial barriers of the skin, gastrointestinal …

[HTML][HTML] Microbiota dysbiosis and barrier dysfunction in inflammatory bowel disease and colorectal cancers: exploring a common ground hypothesis

LCH Yu - Journal of biomedical science, 2018 - Springer
Inflammatory bowel disease (IBD) is a multifactorial disease which arises as a result of the
interaction of genetic, environmental, barrier and microbial factors leading to chronic …

[HTML][HTML] Oral–gut microbiome axis in gastrointestinal disease and cancer

SY Park, BO Hwang, M Lim, SH Ok, SK Lee, KS Chun… - Cancers, 2021 - mdpi.com
Simple Summary Microbiota dysbiosis is correlated with numerous diseases in the human
body. To date, the research on the microbiome-associated diseases been focused on an …

Intestinal epithelial claudins: expression and regulation in homeostasis and inflammation

V Garcia‐Hernandez, M Quiros… - Annals of the New York …, 2017 - Wiley Online Library
The intestinal epithelium forms a highly dynamic and selective barrier that controls
absorption of fluid and solutes while restricting pathogen access to underlying tissues …

[HTML][HTML] Berberine ameliorates DSS-induced intestinal mucosal barrier dysfunction through microbiota-dependence and Wnt/β-catenin pathway

Y Dong, H Fan, Z Zhang, F Jiang, M Li… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disorder of the colon, and it has
become one of the world-recognized medical problems as it is recurrent and refractory …