Cancers | Free Full-Text | Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between
Obesity and Inflammation—Driven Liver and Colorectal Cancers Next Article in Journal Effects …

The liver is a central organ for homeostasis with unique regenerative capacities. Mature
hepatocytes possess a remarkable capacity to proliferate upon injury, challenging efforts to …

Although activity that induced tumor regression was observed and termed tumor necrosis
factor (TNF) as early as the 1960s, the true identity of TNF was not clear until 1984, when …

Heparanase is the only mammalian enzyme that cleaves heparan sulphate, an important
component of the extracellular matrix. This leads to the remodelling of the extracellular …

The increasing incidence of obesity and its co-morbid conditions poses a great challenge to
global health. In addition to cardiovascular disease and diabetes, epidemiological data …

It has been established that cancer can be promoted and/or exacerbated by inflammation
and infections. Indeed, chronic inflammation orchestrates a tumor-supporting …

Inflammation is a crucial function of the innate immune system that protects against
pathogens and initiates specific immunity. Acute inflammation is a rapid and self-limiting …

Tumor-promoting inflammation is one of the hallmarks of cancer. It has been shown that
cancer development is strongly influenced by both chronic and acute inflammation process …

Tumour necrosis factor alpha is a member of the TNF/TNFR cytokine superfamily. In
common with other family members, TNF-α is involved in maintenance and homeostasis of …

Although inflammation has long been known as a localized protective reaction of tissue to
irritation, injury, or infection, characterized by pain, redness, swelling, and sometimes loss of …