Counts of hyaluronic acid-containing extracellular vesicles decrease in naturally occurring equine osteoarthritis

AM Mustonen, N Lehmonen, S Oikari, J Capra… - Scientific Reports, 2022 - nature.com
Osteoarthritis (OA) is a degenerative joint disease with inadequately understood
pathogenesis leading to pain and functional limitations. Extracellular vesicles (EVs) …

Targeted analysis of the size distribution of heavy chain-modified hyaluronan with solid-state nanopores

DA Erxleben, RJ Dodd, AJ Day, DE Green… - Analytical …, 2024 - ACS Publications
The glycosaminoglycan hyaluronan (HA) plays important roles in diverse physiological
functions where the distribution of its molecular weight (MW) can influence its behavior and …

Inflammatory markers for differentiation of endometritis in the mare

J Lection, B Wagner, M Byron, A Miller… - Equine Veterinary …, 2024 - Wiley Online Library
Background Endometrial biopsy is required to diagnose mares with chronic endometritis
and endometrial degenerative fibrosis. An increase in understanding of equine reproductive …

Impact of high-molecular-weight hyaluronic acid on gene expression in rabbit achilles tenocytes in vitro

I Miescher, P Wolint, C Opelz, JG Snedeker… - International Journal of …, 2022 - mdpi.com
(1) Background: Surgical tendon repair often leads to adhesion formation, leading to joint
stiffness and a reduced range of motion. Tubular implants set around sutured tendons might …

Articular cartilage regeneration by hyaline chondrocytes: a case study in equine model and outcomes

F Canonici, C Cocumelli, A Cersini, D Marcoccia… - Biomedicines, 2023 - mdpi.com
Cartilage injury defects in animals and humans result in the development of osteoarthritis
and the progression of joint deterioration. Cell isolation from equine hyaline cartilage and …

Heterogeneous distribution of viscosupplements in vivo is correlated to ex vivo frictional properties of equine cartilage

K Vishwanath, SR McClure… - Journal of Biomedical …, 2024 - Wiley Online Library
Intra‐articular injections of hyaluronic acid (HA) are the cornerstone of osteoarthritis (OA)
treatments. However, the mechanism of action and efficacy of HA viscosupplementation are …

Loss of effective lubricating viscosity is the primary mechanical marker of joint inflammation in equine synovitis

K Vishwanath, EJ Secor, A Watkins… - Journal of …, 2024 - Wiley Online Library
Inflammation of the synovium, known as synovitis, plays an important role in the
pathogenesis of osteoarthritis (OA). Synovitis involves the release of a wide variety of pro …

Cartilage-sparing properties of Equine Omega Complete in an organ culture model of cartilage inflammation

A Garland, C Wierenga, P McCrae… - Journal of Equine …, 2023 - Elsevier
The purpose of this study was to determine anti-inflammatory and/or chondroprotective
effects of Equine Omega Complete (EOC) on cartilage explants stimulated with …

[HTML][HTML] Monoclonal antibody development advances immunological research in horses

B Wagner - Veterinary Immunology and Immunopathology, 2024 - Elsevier
Host immune analyses require specific reagents to identify cellular and soluble components
of the immune system. These immune reagents are often species-specific. For horses …

Morphological and radiological study of the shoulder and elbow joints of the giant anteater (Myrmecophaga tridactyla)

CC Lyra da Silva, JR Cardoso… - Journal of …, 2023 - Wiley Online Library
The giant anteater (Myrmecophaga tridactyla) has specialized thoracic limbs to forage by
breaking the walls of anthills and termite mounds. They also play critical roles in defense …