Over the past 25 years, successive cloning of SLC34A1, SLC34A2 and SLC34A3, which
encode the sodium-dependent inorganic phosphate (Pi) cotransport proteins 2a–2c, has …

Membrane transporters are integral membrane proteins that mediate the passage of solutes
across lipid bilayers. These proteins undergo conformational transitions between outward …

The degree of evolutionary conservation of an amino acid in a protein or a nucleic acid in
DNA/RNA reflects a balance between its natural tendency to mutate and the overall need to …

Citrate is best known as an intermediate in the tricarboxylic acid cycle of the cell. In addition
to this essential role in energy metabolism, the tricarboxylate anion also acts as both a …

The Zrt‐/Irt‐like protein (ZIP) family consists of divalent metal transporters, ubiquitous in all
kingdoms of life. Since the discovery of the first ZIPs in the 1990s, the ZIP family has been …

Citrate, α-ketoglutarate and succinate are TCA cycle intermediates that also play essential
roles in metabolic signaling and cellular regulation. These di-and tricarboxylates are …

Tripartite ATP-independent periplasmic (TRAP) transporters are found widely in bacteria
and archaea and consist of three structural domains, a soluble substrate-binding protein (P …

Tripartite ATP-independent periplasmic (TRAP) transporters are secondary-active
transporters that receive their substrates via a soluble-binding protein to move bioorganic …

Boron is essential for plant growth because of its incorporation into plant cell walls; however,
in excess it is toxic to plants. Boron transport and homeostasis in plants is regulated in part …

Lipid metabolism disorder is closely related to metabolic diseases, inflammation, and
cancer. The concentration of citrate in the cytosol has a significant impact on lipid synthesis …