Myc is a powerful transcription factor implicated in epigenetic reprogramming, cellular
plasticity, and rapid growth as well as tumorigenesis. Cancer in skeletal muscle is extremely …

Heart diseases are a major cause of morbidity and mortality worldwide. Understanding the
molecular mechanisms underlying these diseases is essential for the development of …

Titin, the so‐called “third filament” of the sarcomere, represents a difficult challenge for the
determination of damaging genetic variants. A single titin molecule extends across half the …

In muscular dystrophies, muscle fibers loose integrity and die, causing significant suffering
and premature death. Strikingly, the extraocular muscles (EOMs) are spared, functioning …

Background: Genome-wide association studies have identified hundreds of loci associated
with common vascular diseases, such as coronary artery disease, myocardial infarction, and …

Titin N2B unique sequence (N2B-us) is a 572 amino acid sequence that acts as an elastic
spring to regulate muscle passive elasticity. It is thought to lack stable tertiary structures and …

This review examines the giant elastic protein titin and its critical roles in heart function, both
in health and disease, as discovered since its identification nearly 50 years ago. Encoded by …

The giant protein titin is an essential component of muscle sarcomeres. A single titin
molecule spans half a sarcomere and mediates diverse functions along its length by virtue of …

Transversal structural elements in cross-striated muscles, such as the M-band or the Z-disc,
anchor and mechanically stabilize the contractile apparatus and its minimal unit—the …

The sarcomere is the fundamental contractile unit in skeletal muscle, and the regularity of its
structure is critical for function. Emerging data demonstrates that nanoscale changes to the …