Epidermal Growth Factor Receptor (EGFR) is a transmembrane glycoprotein that constitutes
one of the four members of ErbB family of tyrosine kinase receptors. Activation of EGFR …

Because of the development of drug-resistance mutations, particularly the “gatekeeper”
threonine790-to-methionine790 (T790M) mutation in the ATP-binding pocket of the …

The clinical success of covalent kinase inhibitors in the treatment of EGFR-dependent non-
small cell lung cancer (NSCLC) has rejuvenated the appreciation of reactive small …

In this study, a series of nitric oxide (NO)-releasing 5-cyano-6-phenyl-2, 4-disubstituted
pyrimidine derivatives were designed and synthesized. In the in vitro biological evaluation …

Glucocorticoid-induced osteoporosis (GIOP) is the leading cause of iatrogenic osteoporosis
due to the widespread clinical use of glucocorticoids (GC) as immunosuppressants …

The deregulation of a wide variety of protein kinases is associated with cancer cell initiation
and tumor progression. Owing to their indispensable function in signaling pathways driving …

To search for new drugs for intervention of drug-resistant lung cancer, a series of hybrids 4-
15 from 2-cyano-3, 12-dioxooleana-9-dien-28-oic acid (CDDO) and O 2-(2, 4-dinitrophenyl) …

By taking advantage of good affinity of oleanolic acid (OA) to the bile acid transporter, a
series of hybrid compounds from oleanolic acid (OA) or OA-nitric oxide (NO) donor …

Recent reports suggested that essential directions for new lung cancer, breast carcinoma
therapies, as well as the roomier realm of targeted cancer therapies were provided through …

Nitric oxide (NO) is a gaseous molecule integral to numerous physiological processes,
including tumor modulation, cardiovascular regulation, and systemic physiological functions …