Mutations and mechanisms of WNT pathway tumour suppressors in cancer
Mutation-induced activation of WNT–β-catenin signalling is a frequent driver event in human
cancer. Sustained WNT–β-catenin pathway activation endows cancer cells with sustained …
cancer. Sustained WNT–β-catenin pathway activation endows cancer cells with sustained …
Molecular mechanisms of colon cancer progression and metastasis: recent insights and advancements
Colorectal cancer (CRC), the third most common type of cancer, is the second leading cause
of cancer-related mortality rates worldwide. Although modern research was able to shed …
of cancer-related mortality rates worldwide. Although modern research was able to shed …
Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer
The consensus molecular subtype (CMS) classification of colorectal cancer is based on bulk
transcriptomics. The underlying epithelial cell diversity remains unclear. We analyzed …
transcriptomics. The underlying epithelial cell diversity remains unclear. We analyzed …
WNT as a driver and dependency in cancer
The WNT signaling pathway is a critical regulator of development and adult tissue
homeostasis and becomes dysregulated in many cancer types. Although hyperactivation of …
homeostasis and becomes dysregulated in many cancer types. Although hyperactivation of …
Systematic profiling of conditional pathway activation identifies context-dependent synthetic lethalities
L Chang, NY Jung, A Atari, DJ Rodriguez, D Kesar… - Nature Genetics, 2023 - nature.com
The paradigm of cancer-targeted therapies has focused largely on inhibition of critical
pathways in cancer. Conversely, conditional activation of signaling pathways as a new …
pathways in cancer. Conversely, conditional activation of signaling pathways as a new …
Wnt signaling in cancer
Wnt signaling is one of the key cascades regulating development and stemness, and has
also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has …
also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has …
Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells
U Testa, E Pelosi, G Castelli - Medical Sciences, 2018 - mdpi.com
Colon cancer is the third most common cancer worldwide. Most colorectal cancer
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …
[HTML][HTML] Apc restoration promotes cellular differentiation and reestablishes crypt homeostasis in colorectal cancer
LE Dow, KP O'Rourke, J Simon, DF Tschaharganeh… - Cell, 2015 - cell.com
The adenomatous polyposis coli (APC) tumor suppressor is mutated in the vast majority of
human colorectal cancers (CRC) and leads to deregulated Wnt signaling. To determine …
human colorectal cancers (CRC) and leads to deregulated Wnt signaling. To determine …
[HTML][HTML] Colorectal cancer carcinogenesis: a review of mechanisms
Colorectal cancer (CRC) is the second most common cancer in women and the third most
common in men globally. CRC arises from one or a combination of chromosomal instability …
common in men globally. CRC arises from one or a combination of chromosomal instability …