During evolution, the cerebral cortex advances by increasing in surface and the introduction
of new cytoarchitectonic areas among which the prefrontal cortex (PFC) is considered to be …

Brain organoids are self-assembled three-dimensional aggregates generated from
pluripotent stem cells with cell types and cytoarchitectures that resemble the embryonic …

Human brain organoids provide unique platforms for modeling development and diseases
by recapitulating the architecture of the embryonic brain. However, current organoid …

The mammalian prefrontal cortex comprises a set of highly specialized brain areas
containing billions of cells and serves as the centre of the highest-order cognitive functions …

The cerebral cortex constitutes more than half the volume of the human brain and is
presumed to be responsible for the neuronal computations underlying complex phenomena …

The human CNS follows a pattern of development typical of all mammals, but certain
neurodevelopmental features are highly derived. Building the human CNS requires the …

We performed RNA sequencing on 40,000 cells to create a high-resolution single-cell gene
expression atlas of developing human cortex, providing the first single-cell characterization …

Early brain development, from the embryonic period to infancy, is characterized by rapid
structural and functional changes. These changes can be studied using structural and …

The size and shape of dendrites and axons are strong determinants of neuronal information
processing. Our knowledge on neuronal structure and function is primarily based on brains …

Ectopic expression of defined transcription factors can force direct cell-fate conversion from
one lineage to another in the absence of cell division. Several transcription factor cocktails …