Monoclonal antibodies (mAbs) are subject to instability issues linked to their protein nature.
In this work, we review the different mechanisms that can be linked to monoclonal antibodies …

Adequate stabilization is essential for marketed protein-based biopharmaceutical
formulations to withstand the various stresses that can be exerted during the pre-and post …

Histidine, a widely used buffer in monoclonal antibody (mAb) formulations, is known to
reduce antibody aggregation. While experimental studies suggest a nonelectrostatic …

Tangential flow filtration is an efficient membrane separation technology utilized across a
wide range of industries for separation and purification applications. The requirement of …

The human angiotensin-converting enzyme 2 acts as the host cell receptor for SARS-CoV-2
and the other members of the Coronaviridae family SARS-CoV-1 and HCoV-NL63. Here, we …

Monoclonal antibodies are proteinaceous in nature and are subject to instability issues.
Stability testing of monoclonal antibodies is a critical regulatory requirement in their …

Excipients are substances that are added to therapeutic products to improve stability,
bioavailability, and manufacturability. Undesirable protein–protein interactions (PPI) can …

Monoclonal antibodies are susceptible to chemical and enzymatic modifications during
manufacturing, storage, and shipping. Deamidation, isomerization, and oxidation can …

The main objective of this work was to explore the feasibility to print monoclonal antibody
(mAb)-loaded implantable systems using fused-deposition modelling (FDM) to build …

The solution viscosity and protein–protein interactions (PPIs) as a function of temperature (4–
40° C) were measured at a series of protein concentrations for a monoclonal antibody (mAb) …