Obesity has tripled over the past 40 years to become a major public health issue, as it is
linked with increased mortality and elevated risk for various physical and neuropsychiatric …

Abstract Type 2 diabetes (T2D) and its target organ injuries cause distressing impacts on
personal health and put an enormous burden on the healthcare system, and increasing …

Obesity is a risk factor for neurodegenerative disease associated with cognitive dysfunction,
including Alzheimer's disease. Low-grade inflammation is common in obesity, but the …

There is increasing interest in factors that may modulate white matter (WM) breakdown and,
consequentially, age-related cognitive and behavioral deficits. Recent diffusion tensor …

Abstract Some Diffusion Tensor Imaging studies have shown a loss of white matter (WM)
integrity linked to impaired cognitive function in obese individuals. However, inconsistent …

Obesity has a major impact on metabolic health thereby negatively affecting brain function
and structure, however mechanisms involved are not entirely understood. The increasing …

Cognition underpins the flexibility of human eating and disruption to higher cognitive
processes, such as inhibitory control and memory, and can result in increased food intake …

Obesity constitutes a major global health threat. Despite the success of bariatric surgery in
delivering sustainable weight loss and improvement in obesity-related morbidity, effective …

Ever since Claude Bernards discovery in the mid 19th-century that a lesion in the floor of the
third ventricle in dogs led to altered systemic glucose levels, a role of the CNS in whole-body …

Obese individuals exhibit brain functional abnormalities in multiple regions implicated in
reward/motivation, emotion/memory, homeostatic regulation, and executive control when …