Regulation of liver X receptor target genes by 22-functionalized oxysterols. Synthesis, in silico and in vitro evaluations

EÖ Viktorsson, M Gabrielsen, N Kumarachandran… - Steroids, 2017 - Elsevier
Abstract The endogenous oxysterol 22 (R)-hydroxycholesterol (22RHC, 1) is an LXR agonist
which upregulates genes of critical involvement in human cholesterol-and lipid metabolism …