Background Acupuncture is often used for migraine prevention but its effectiveness is still
controversial. We present an update of our Cochrane review from 2009. Objectives To …

Introduction Combination use of onabotulinumtoxinA and calcitonin gene–related peptide
(CGRP) monoclonal antibodies (mAbs) has the potential to be more effective than either …

Objective To incorporate recent research findings, expert consensus, and patient
perspectives into updated guidance on the use of new acute and preventive treatments for …

Background Many patients who require migraine preventive treatment have not been able to
tolerate or have not responded to multiple previous preventive medications. We aimed to …

Objective To evaluate the efficacy and safety of galcanezumab, a humanized monoclonal
antibody that selectively binds to calcitonin gene-related peptide, in the preventive treatment …

Background Calcitonin gene-related peptide plays an important role in migraine
pathophysiology. Erenumab, a human monoclonal antibody that inhibits the calcitonin gene …

Background and purpose Although erenumab has demonstrated significant reduction in
migraine frequency and improved quality of life in studies lasting 3 to 12 months, little is …

Objective To provide healthcare professionals with updated guidance in the use of novel
preventive and acute treatments for migraine in adults. Background The principles of …

Background Quality clinical trials form an essential part of the evidence base for the
treatment of headache disorders. In 1991, the International Headache Society Clinical Trials …

Importance Migraine is the second leading cause of disability worldwide. Most patients with
migraine discontinue medications due to inefficacy or adverse effects. Mindfulness-based …