Therapies modulating the immune system offer the prospect of treating a wide range of
conditions including infectious diseases, cancer and autoimmunity. Biomaterials can …

Covalent organic frameworks (COFs) are porous organic polymeric materials that are
composed of organic elements and linked together by the thermodynamically stable …

Nanoparticle-based mRNA therapeutics hold great promise, but cellular internalization and
endosomal escape remain key barriers for cytosolic delivery. We developed a dual …

Cancer immunotherapies including cancer vaccines, immune checkpoint blockade or
chimeric antigen receptor T cells have been exploited as the attractive treatment modalities …

Cancer immunotherapy has gained momentum for treating malignant tumors over the past
decade. Checkpoint blockade and chimeric antigen receptor cell therapy (CAR-T) have …

T cells are often referred to as the 'guided missiles' of our immune system because of their
capacity to traffic to and accumulate at sites of infection or disease, destroy infected or …

Abstract mRNA gene therapy has recently emerged as a candidate to enable multiple
therapeutic applications including protein replacement therapy, vaccine immunology, and …

Modulation of the immune system is an important therapeutic strategy in a wide range of
diseases, and is fundamental to the development of vaccines. However, optimally safe and …

Immuno-oncology therapies have been of great interest with the goal of inducing sustained
tumor regression, but clinical results have demonstrated the need for improved and widely …

Advances in understanding how cancer cells interact with the immune system allowed the
development of immunotherapeutic strategies, harnessing patients' immune system to fight …