Transient receptor potential channels as therapeutic targets

MM Moran, MA McAlexander, T Bíró… - Nature reviews Drug …, 2011 - nature.com
Transient receptor potential (TRP) cation channels have been among the most aggressively
pursued drug targets over the past few years. Although the initial focus of research was on …

American Burn Association guidelines on the management of acute pain in the adult burn patient: a review of the literature, a compilation of expert opinion, and next …

KS Romanowski, J Carson, K Pape… - Journal of Burn Care …, 2020 - academic.oup.com
The ABA pain guidelines were developed 14 years ago and have not been revised despite
evolution in the practice of burn care. A sub-committee of the American Burn Association's …

Structural mechanisms of TRPM7 activation and inhibition

KD Nadezhdin, L Correia, C Narangoda… - Nature …, 2023 - nature.com
The transient receptor potential channel TRPM7 is a master regulator of the organismal
balance of divalent cations that plays an essential role in embryonic development, immune …

TRPM7 is essential for Mg2+ homeostasis in mammals

LV Ryazanova, LJ Rondon, S Zierler, Z Hu… - Nature …, 2010 - nature.com
Mg2+ is the second-most abundant cation in animal cells and is an essential cofactor in
numerous enzymatic reactions. The molecular mechanisms controlling Mg2+ balance in the …

Regulation of magnesium balance: lessons learned from human genetic disease

JHF De Baaij, JGJ Hoenderop… - Clinical kidney …, 2012 - academic.oup.com
Abstract Magnesium (Mg2+) is the fourth most abundant cation in the body. Thus,
magnesium homeostasis needs to be tightly regulated, and this is facilitated by intestinal …

TRPM7 kinase activity induces amyloid-β degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer's disease

S Zhang, F Cao, W Li, N Abumaria - Science signaling, 2023 - science.org
Altered abundance or activity of the dual-function transient receptor potential melastatin-like
7 (TRPM7) protein is implicated in neurodegenerative disorders, including Alzheimer's …

[HTML][HTML] TRPM6 and TRPM7—Gatekeepers of human magnesium metabolism

KP Schlingmann, S Waldegger, M Konrad… - … et Biophysica Acta (BBA …, 2007 - Elsevier
Human magnesium homeostasis primarily depends on the balance between intestinal
absorption and renal excretion. Magnesium transport processes in both organ systems–next …

Transient receptor potential channelopathies

B Nilius, G Owsianik - Pflügers Archiv-European Journal of Physiology, 2010 - Springer
In the past years, several hereditary diseases caused by defects in transient receptor
potential channels (TRP) genes have been described. This review summarizes our current …

Molecular identification of ancient and modern mammalian magnesium transporters

GA Quamme - American Journal of Physiology-Cell …, 2010 - journals.physiology.org
A large number of mammalian Mg2+ transporters have been hypothesized on the basis of
physiological data, but few have been investigated at the molecular level. The recent …

Recent developments in intestinal magnesium absorption

GA Quamme - Current opinion in gastroenterology, 2008 - journals.lww.com
Recent developments in intestinal magnesium absorption : Current Opinion in Gastroenterology
Recent developments in intestinal magnesium absorption : Current Opinion in Gastroenterology …