The roles and implications of RNA m6A modification in cancer
Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
m6A modification: recent advances, anticancer targeted drug discovery and beyond
LJ Deng, WQ Deng, SR Fan, MF Chen, M Qi, WY Lyu… - Molecular cancer, 2022 - Springer
Abstract Abnormal N6-methyladenosine (m6A) modification is closely associated with the
occurrence, development, progression and prognosis of cancer, and aberrant m6A …
occurrence, development, progression and prognosis of cancer, and aberrant m6A …
METTL3/IGF2BP3 axis inhibits tumor immune surveillance by upregulating N6-methyladenosine modification of PD-L1 mRNA in breast cancer
W Wan, X Ao, Q Chen, Y Yu, L Ao, W Xing, W Guo… - Molecular cancer, 2022 - Springer
Background Continual expression of PD-L1 in tumor cells is critical for tumor immune
escape and host T cell exhaustion, however, knowledge on its clinical benefits through …
escape and host T cell exhaustion, however, knowledge on its clinical benefits through …
m6A RNA methylation: from mechanisms to therapeutic potential
RNA carries a diverse array of chemical modifications that play important roles in the
regulation of gene expression. N 6‐methyladenosine (m6A), installed onto mRNA by the …
regulation of gene expression. N 6‐methyladenosine (m6A), installed onto mRNA by the …
The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities
RNA modifications have recently emerged as critical posttranscriptional regulators of gene
expression programmes. Significant advances have been made in understanding the …
expression programmes. Significant advances have been made in understanding the …
Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma
Background Histone lactylation, a metabolic stress-related histone modification, plays an
important role in the regulation of gene expression during M1 macrophage polarization …
important role in the regulation of gene expression during M1 macrophage polarization …
[HTML][HTML] Neutrophil extracellular traps mediate m6A modification and regulates sepsis-associated acute lung injury by activating ferroptosis in alveolar epithelial cells
H Zhang, J Liu, Y Zhou, M Qu, Y Wang… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Neutrophil extracellular traps (NETs) production is a major strategy employed by
polymorphonuclear neutrophils (PMNs) to fight against microbes. NETs have been …
polymorphonuclear neutrophils (PMNs) to fight against microbes. NETs have been …
Role of RNA modifications in cancer
I Barbieri, T Kouzarides - Nature Reviews Cancer, 2020 - nature.com
Specific chemical modifications of biological molecules are an efficient way of regulating
molecular function, and a plethora of downstream signalling pathways are influenced by the …
molecular function, and a plethora of downstream signalling pathways are influenced by the …
m6A modification in coding and non-coding RNAs: roles and therapeutic implications in cancer
N 6-Methyladenosine (m 6 A) RNA modification has emerged in recent years as a new layer
of regulatory mechanism controlling gene expression in eukaryotes. As a reversible …
of regulatory mechanism controlling gene expression in eukaryotes. As a reversible …
The potential role of RNA N6-methyladenosine in Cancer progression
T Wang, S Kong, M Tao, S Ju - Molecular cancer, 2020 - Springer
Abstract N6-methyladenosine (m6A) is considered the most common, abundant, and
conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA) …
conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA) …